The Role of TGFβ in Bone-Muscle Crosstalk

Jenna Regan, Trupti Trivedi, Theresa Guise, David L. Waning

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Purpose of Review: The role of bone-derived factors in regulation of skeletal muscle function is an important emerging aspect of research into bone-muscle crosstalk. Implications for this area of research are far reaching and include understanding skeletal muscle weakness in cancer, osteoporosis, cachexia, rare diseases of bone, and aging. Recent Findings: Recent research shows that bone-derived factors can lead to changes in the skeletal muscle. These changes can either be anabolic or catabolic, and we focus this review on the role of TGFβ in driving oxidative stress and skeletal muscle weakness in the setting of osteolytic cancer in the bone. Summary: The bone is a preferred site for breast cancer metastasis and leads to pathological bone loss. Osteolytic cancer in the bone leads to release of TGFβ from the bone via osteoclast-mediated bone destruction. Our appreciation of crosstalk between the muscle and bone has recently expanded beyond mechanical force-driven events to encompass a variety of signaling factors originating in one tissue and communicating to the other. This review summarizes some previously known mediators of bone-to-muscle signaling and also recent work identifying a new role for bone-derived TGFβ as a cause of skeletal muscle weakness in the setting of osteolytic cancer in the bone. Multiple points of potential therapeutic intervention are discussed.

Original languageEnglish (US)
Pages (from-to)18-23
Number of pages6
JournalCurrent Osteoporosis Reports
Volume15
Issue number1
DOIs
StatePublished - Feb 1 2017

Fingerprint

Bone and Bones
Muscles
Skeletal Muscle
Bone Neoplasms
Muscle Weakness
Research
Cachexia
Osteoclasts
Rare Diseases
Osteoporosis
Oxidative Stress
Breast Neoplasms
Neoplasm Metastasis
Neoplasms

Keywords

  • Bone
  • Bone-muscle crosstalk
  • Skeletal muscle
  • TGFβ

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

The Role of TGFβ in Bone-Muscle Crosstalk. / Regan, Jenna; Trivedi, Trupti; Guise, Theresa; Waning, David L.

In: Current Osteoporosis Reports, Vol. 15, No. 1, 01.02.2017, p. 18-23.

Research output: Contribution to journalReview article

Regan, Jenna ; Trivedi, Trupti ; Guise, Theresa ; Waning, David L. / The Role of TGFβ in Bone-Muscle Crosstalk. In: Current Osteoporosis Reports. 2017 ; Vol. 15, No. 1. pp. 18-23.
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