The Role of the Immune System in the Effects of Cancer on Bone

Rebecca Silbermann, G. David Roodman

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In this chapter, the contributions of cells in the immune system (monocyte-macrophages, myeloid derived suppressor cells, mesenchymal stromal cells, T cell subsets, NK cells, dendritic cells, and B cells) to bone metastasis, and multiple myeloma bone disease will be reviewed. In addition, the effects of tumor-derived products, such as lactic acid, that is also produced by bone cells, on the suppression of antitumor responses that are required for tumor growth in bone, will be discussed. All of these components of the immune system are major contributors to the growth and bone altering effects of tumor cells in bone.

Original languageEnglish (US)
Title of host publicationOsteoimmunology: Interactions of the Immune and Skeletal Systems: Second Edition
PublisherElsevier Inc.
Pages311-324
Number of pages14
ISBN (Print)9780128005712
DOIs
StatePublished - Oct 6 2015

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Bone Neoplasms
Immune System
Bone Development
Bone and Bones
Neoplasms
Bone Diseases
T-Lymphocyte Subsets
Multiple Myeloma
Mesenchymal Stromal Cells
Natural Killer Cells
Dendritic Cells
Monocytes
Lactic Acid
B-Lymphocytes
Macrophages
Neoplasm Metastasis

Keywords

  • Dendritic cells
  • Immune system
  • Macrophage
  • Metastasis
  • Multiple myeloma
  • Tumor cells

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Silbermann, R., & Roodman, G. D. (2015). The Role of the Immune System in the Effects of Cancer on Bone. In Osteoimmunology: Interactions of the Immune and Skeletal Systems: Second Edition (pp. 311-324). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800571-2.00018-9

The Role of the Immune System in the Effects of Cancer on Bone. / Silbermann, Rebecca; Roodman, G. David.

Osteoimmunology: Interactions of the Immune and Skeletal Systems: Second Edition. Elsevier Inc., 2015. p. 311-324.

Research output: Chapter in Book/Report/Conference proceedingChapter

Silbermann, R & Roodman, GD 2015, The Role of the Immune System in the Effects of Cancer on Bone. in Osteoimmunology: Interactions of the Immune and Skeletal Systems: Second Edition. Elsevier Inc., pp. 311-324. https://doi.org/10.1016/B978-0-12-800571-2.00018-9
Silbermann R, Roodman GD. The Role of the Immune System in the Effects of Cancer on Bone. In Osteoimmunology: Interactions of the Immune and Skeletal Systems: Second Edition. Elsevier Inc. 2015. p. 311-324 https://doi.org/10.1016/B978-0-12-800571-2.00018-9
Silbermann, Rebecca ; Roodman, G. David. / The Role of the Immune System in the Effects of Cancer on Bone. Osteoimmunology: Interactions of the Immune and Skeletal Systems: Second Edition. Elsevier Inc., 2015. pp. 311-324
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