The Role of the Osteocyte in Bone and Nonbone Disease

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

When normal physiologic functions go awry, disorders and disease occur. This is universal; even for the osteocyte, a cell embedded within the mineralized matrix of bone. It was once thought that this cell was simply a placeholder in bone. Within the last decade, the number of studies of osteocytes has increased dramatically, leading to the discovery of novel functions of these cells. With the discovery of novel physiologic functions came the discoveries of how these cells can also be responsible for not only bone diseases and disorders, but also those of the kidney, heart, and potentially muscle.

Original languageEnglish (US)
Pages (from-to)1-18
Number of pages18
JournalEndocrinology and Metabolism Clinics of North America
Volume46
Issue number1
DOIs
StatePublished - Mar 1 2017

Keywords

  • Bone disease
  • FGF23
  • Osteocyte
  • Sclerostin
  • Therapeutics

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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