The role of TRP channels in migraine

Gerry Stephen Oxford, Joyce Hurley

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

TRP channels are members of a large family of non-selective cation channels. The family which numbers over 30 is classified into 6 groups based on amino acid sequence homology. TRP channels are distributed in many peripheral tissues as well as central and peripheral nervous system. These channels are important in sensing a wide range of chemical and physical stimuli. Several TRP channels, including TRPV1 and TRPA1 are important in pain transduction pathways. This review will focus on the function of TRP channels in the trigeminovascular system and other anatomical regions which are relevant to migraine. We will discuss the possible role of TRP channels in migraine, including the potential role of TRPV1 in the hypersensitivity and allodynia frequently observed in migraine patients. We will review the status of TRP channel drugs in migraine therapeutics. We will also discuss the possible roles of TRP channels in triggering migraine attacks, a process which is not well-understood.

Original languageEnglish
Pages (from-to)37-49
Number of pages13
JournalOpen Pain Journal
Volume6
Issue numberSPEC.ISSUE.1
DOIs
StatePublished - 2013

Fingerprint

Migraine Disorders
Amino Acid Sequence Homology
Hyperalgesia
Peripheral Nervous System
Cations
Hypersensitivity
Central Nervous System
Pain
Pharmaceutical Preparations
Therapeutics

Keywords

  • Inflammation
  • Migraine
  • Neurogenic
  • Pain
  • Trigeminal
  • TRP receptor

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Anesthesiology and Pain Medicine

Cite this

The role of TRP channels in migraine. / Oxford, Gerry Stephen; Hurley, Joyce.

In: Open Pain Journal, Vol. 6, No. SPEC.ISSUE.1, 2013, p. 37-49.

Research output: Contribution to journalArticle

Oxford, Gerry Stephen ; Hurley, Joyce. / The role of TRP channels in migraine. In: Open Pain Journal. 2013 ; Vol. 6, No. SPEC.ISSUE.1. pp. 37-49.
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