The Ror receptor tyrosine kinase family

Research output: Contribution to journalReview article

82 Scopus citations

Abstract

Receptor tyrosine kinases (RTKs) participate in numerous developmental decisions. Ror RTKs are a family of orphan receptors that are related to muscle specific kinase (MuSK) and Trk neurotrophin receptors. MuSK assembles acetylcholine receptors at the neuromuscular junction [1,2], and Trk receptors function in the developing nervous system (reviewed in [3-5]). Rors have been identified in nematodes, insects and mammals. Recent studies have begun to shed light on Ror function during development. In most species, Rors are expressed in many tissue types during development. Analyses of mutants that are defective in the single nematode Ror demonstrate a role in cell migration and in orienting cell polarity. Mice lacking one of the two Ror gene products display defects in bone and heart formation. Similarly, two different human bone development disorders, dominant brachydactyly B and recessive Robinow syndrome, result from mutations in one of the human Ror genes.

Original languageEnglish (US)
Pages (from-to)83-96
Number of pages14
JournalCellular and Molecular Life Sciences
Volume59
Issue number1
DOIs
StatePublished - Feb 12 2002

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Keywords

  • Bone development
  • Brachydactyly B
  • Cell migration
  • Cell polarity
  • Robinow syndrome

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

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