The rs6771157 C/G polymorphism in SCN10A is associated with the risk of atrial fibrillation in a Chinese Han population

Zhen Fang, Yue Jiang, Yifeng Wang, Yuan Lin, Yaowu Liu, Liyan Zhao, Yan Xu, Mohammad Bilaal Toorabally, Shenghu He, Fengxiang Zhang

Research output: Contribution to journalArticle

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Abstract

A recent genome wide associated study in European descent population identified the association of Atrial fibrillation (AF) risk with a single nucleotide polymorphism (SNP) in SCN10A. The aim of this study was to evaluate whether SCN10A polymorphisms are associated with AF risk in the Chinese Han population. A total of 2,300 individuals of Chinese Han origin were recruited and three potentially functional SNPs were genotyped. Logistic regression models were utilized to calculate odds ratios (ORs) at a 95% confidence intervals (CIs). Logistic regression analysis in an additive genetic model revealed that one SNP in SCN10A (rs6771157) was associated with an increased risk of AF (adjusted OR = 1.20, 95% CI: 1.06-1.36, P = 0.003). Stratification analysis of several main AF risk factors indicated that the risk associations with rs6771157 were not statistically different among different subgroups. In summary, our study suggests the possible involvement of the SCN10A variant in AF development in Chinese Han populations. Further biological function analyses are required to confirm our finding.

Original languageEnglish (US)
Article number35212
JournalScientific Reports
Volume6
DOIs
StatePublished - Oct 11 2016
Externally publishedYes

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Atrial Fibrillation
Single Nucleotide Polymorphism
Population
Logistic Models
Odds Ratio
Confidence Intervals
Genetic Models
Regression Analysis
Genome

ASJC Scopus subject areas

  • General

Cite this

The rs6771157 C/G polymorphism in SCN10A is associated with the risk of atrial fibrillation in a Chinese Han population. / Fang, Zhen; Jiang, Yue; Wang, Yifeng; Lin, Yuan; Liu, Yaowu; Zhao, Liyan; Xu, Yan; Toorabally, Mohammad Bilaal; He, Shenghu; Zhang, Fengxiang.

In: Scientific Reports, Vol. 6, 35212, 11.10.2016.

Research output: Contribution to journalArticle

Fang, Zhen ; Jiang, Yue ; Wang, Yifeng ; Lin, Yuan ; Liu, Yaowu ; Zhao, Liyan ; Xu, Yan ; Toorabally, Mohammad Bilaal ; He, Shenghu ; Zhang, Fengxiang. / The rs6771157 C/G polymorphism in SCN10A is associated with the risk of atrial fibrillation in a Chinese Han population. In: Scientific Reports. 2016 ; Vol. 6.
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abstract = "A recent genome wide associated study in European descent population identified the association of Atrial fibrillation (AF) risk with a single nucleotide polymorphism (SNP) in SCN10A. The aim of this study was to evaluate whether SCN10A polymorphisms are associated with AF risk in the Chinese Han population. A total of 2,300 individuals of Chinese Han origin were recruited and three potentially functional SNPs were genotyped. Logistic regression models were utilized to calculate odds ratios (ORs) at a 95{\%} confidence intervals (CIs). Logistic regression analysis in an additive genetic model revealed that one SNP in SCN10A (rs6771157) was associated with an increased risk of AF (adjusted OR = 1.20, 95{\%} CI: 1.06-1.36, P = 0.003). Stratification analysis of several main AF risk factors indicated that the risk associations with rs6771157 were not statistically different among different subgroups. In summary, our study suggests the possible involvement of the SCN10A variant in AF development in Chinese Han populations. Further biological function analyses are required to confirm our finding.",
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AU - Lin, Yuan

AU - Liu, Yaowu

AU - Zhao, Liyan

AU - Xu, Yan

AU - Toorabally, Mohammad Bilaal

AU - He, Shenghu

AU - Zhang, Fengxiang

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