The SaeRS two-component system of Staphylococcus aureus

Qian Liu, Won Sik Yeo, Taeok Bae

Research output: Contribution to journalReview article

42 Citations (Scopus)

Abstract

In the Gram-positive pathogenic bacterium Staphylococcus aureus, the SaeRS two-component system (TCS) plays a major role in controlling the production of over 20 virulence factors including hemolysins, leukocidins, superantigens, surface proteins, and proteases. The SaeRS TCS is composed of the sensor histidine kinase SaeS, response regulator SaeR, and two auxiliary proteins SaeP and SaeQ. Since its discovery in 1994, the sae locus has been studied extensively, and its contributions to staphylococcal virulence and pathogenesis have been well documented and understood; however, the molecular mechanism by which the SaeRS TCS receives and processes cognate signals is not. In this article, therefore, we review the literature focusing on the signaling mechanism and its interaction with other global regulators.

Original languageEnglish (US)
Article number81
JournalGenes
Volume7
Issue number10
DOIs
StatePublished - Oct 1 2016

Fingerprint

Leukocidins
Superantigens
Hemolysin Proteins
Gram-Positive Bacteria
Virulence Factors
Virulence
Staphylococcus aureus
Membrane Proteins
Peptide Hydrolases
Proteins
Histidine Kinase

Keywords

  • Bacterial histidine kinase
  • Staphylococcus aureus
  • Two-component system
  • Virulence factors

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

The SaeRS two-component system of Staphylococcus aureus. / Liu, Qian; Yeo, Won Sik; Bae, Taeok.

In: Genes, Vol. 7, No. 10, 81, 01.10.2016.

Research output: Contribution to journalReview article

Liu, Qian ; Yeo, Won Sik ; Bae, Taeok. / The SaeRS two-component system of Staphylococcus aureus. In: Genes. 2016 ; Vol. 7, No. 10.
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