The SaeRS two-component system of Staphylococcus aureus

Qian Liu, Won Sik Yeo, Taeok Bae

Research output: Contribution to journalReview article

60 Scopus citations


In the Gram-positive pathogenic bacterium Staphylococcus aureus, the SaeRS two-component system (TCS) plays a major role in controlling the production of over 20 virulence factors including hemolysins, leukocidins, superantigens, surface proteins, and proteases. The SaeRS TCS is composed of the sensor histidine kinase SaeS, response regulator SaeR, and two auxiliary proteins SaeP and SaeQ. Since its discovery in 1994, the sae locus has been studied extensively, and its contributions to staphylococcal virulence and pathogenesis have been well documented and understood; however, the molecular mechanism by which the SaeRS TCS receives and processes cognate signals is not. In this article, therefore, we review the literature focusing on the signaling mechanism and its interaction with other global regulators.

Original languageEnglish (US)
Article number81
Issue number10
StatePublished - Oct 2016


  • Bacterial histidine kinase
  • Staphylococcus aureus
  • Two-component system
  • Virulence factors

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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