The sequence and structure of a new serum amyloid a gene

Robert S. Stearman, Clifford A. Lowell, Cynthia G. Peltzman, John F. Morrow

Research output: Contribution to journalArticle

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Abstract

The acute phase response is characterized by changes in the serum concentrations of many proteins. A 1000-fold increase in the concentration of ssrum amyloid A (SAA) protein occurs within 24 hours of LPS injection in the mouse. We have isolated a cDHA clone and its corresponding genomic phage for a third, previously unreported SAA protein. The sequences of the cDNA, the gene's exons and neighboring DHA are presented along with the mapping evidence supporting the gene structure.

Original languageEnglish (US)
Pages (from-to)797-809
Number of pages13
JournalNucleic acids research
Volume14
Issue number2
DOIs
StatePublished - Jan 26 1986

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ASJC Scopus subject areas

  • Genetics

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