The serine/threonine phosphatases of apicomplexan parasites

Chunlin Yang, Gustavo Arrizabalaga

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The balance between phosphorylation and de-phosphorylation, which is delicately regulated by protein kinases and phosphatases, is critical for nearly all biological processes. The Apicomplexa are a large phylum which contains various parasitic protists, including human pathogens, such as Plasmodium, Toxoplasma, Cryptosporidium and Babesia species. The diverse life cycles of these parasites are highly complex and, not surprisingly, many of their key steps are exquisitely regulated by phosphorylation. Interestingly, many of the kinases and phosphatases, as well as the substrates involved in these events are unique to the parasites and therefore phosphorylation constitutes a viable target for antiparasitic intervention. Most progress on this realm has come from studies in Toxoplasma and Plasmodium of their respective kinomes and phosphoproteomes. Nonetheless, given their likely importance, phosphatases have recently become the focus of research within the apicomplexan parasites. In this review, we concentrate on serine/threonine phosphatases in apicomplexan parasites, with the focus on comprehensively identifying and naming protein phosphatases in available apicomplexan genomes, and summarizing the progress of their functional analyses in recent years.

Original languageEnglish (US)
Pages (from-to)1-21
Number of pages21
JournalMolecular Microbiology
Volume106
Issue number1
DOIs
StatePublished - Oct 1 2017

Fingerprint

Phosphoprotein Phosphatases
Parasites
Phosphorylation
Plasmodium
Toxoplasma
Phosphoric Monoester Hydrolases
Apicomplexa
Biological Phenomena
Babesia
Antiparasitic Agents
Cryptosporidium
Life Cycle Stages
Protein Kinases
Phosphotransferases
Genome
Research

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

Cite this

The serine/threonine phosphatases of apicomplexan parasites. / Yang, Chunlin; Arrizabalaga, Gustavo.

In: Molecular Microbiology, Vol. 106, No. 1, 01.10.2017, p. 1-21.

Research output: Contribution to journalReview article

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