The Seroprevalence of Helicobacter pylori in a Referral Population of Children in the United States

Sonny K F Chong, Qinyuan Lou, Terrell W. Zollinger, Simon Rabinowitz, Rima Jibaly, Vasundhara Tolia, Yoram Elitsur, Benjamin D. Gold, Allan Rosenberg, Abiodun Johnson, Orit Elkayam, Philip Rosenthal, Mark Gilger, B. U K Li, Jeffrey S. Peacock

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

OBJECTIVES: The purpose of this study was to determine the prevalence of serum antibodies directed against Helicobacter pylori (H. pylori) in children referred to children's hospitals or medical centers throughout the United States. METHODS: This multisite cross-sectional prospective study involved 992 children from 12 states using a validated anti-H. pylori IgG enzyme immunoassay. The children were recruited into two groups: those without any GI complaints (non-GI referral, n = 619) and those who were referred for endoscopy because of abdominal pain (GI referral, n = 373). RESULTS: GI referral children had a higher rate of seropositivity (22.5%) than non-GI referral children (14.1%) from the same geographic regions. In both groups, older children were more likely to be seropositive for H. pylori, as were nonwhite children and those with lower socioeconomic status. H. pylori seropositivity rates were higher in GI referral children with four or more household members (relative risk [RR] = 1.47; CI 1.01-2.14). Multivariate analysis controlling for age, ethnicity, and household income, showed that presence of GI symptoms were associated with a nearly 2-fold risk for H. pylori seropositivity (odds ratio = 1.77, CI 1.27-2.47). Epigastric pain (RR = 2.21; CI = 1.33-3.66) and having three or more episodes of abdominal pain in the last 3 months (RR = 0.59, CI = 0.35-0.99) were the only specific symptoms significantly associated with H. pylori seropositivity. CONCLUSIONS: The H. pylori seropositivity rate of GI referral children with symptoms of abdominal pain was significantly higher. H. pylori infection in early childhood was found to be associated primarily with the child's household size and socioeconomic status.

Original languageEnglish (US)
Pages (from-to)2162-2168
Number of pages7
JournalAmerican Journal of Gastroenterology
Volume98
Issue number10
DOIs
StatePublished - Oct 2003
Externally publishedYes

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Seroepidemiologic Studies
Helicobacter pylori
Referral and Consultation
Population
Abdominal Pain
Social Class
Helicobacter Infections
Immunoenzyme Techniques
Endoscopy
Multivariate Analysis
Cross-Sectional Studies
Immunoglobulin G
Odds Ratio
Prospective Studies
Pain

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Chong, S. K. F., Lou, Q., Zollinger, T. W., Rabinowitz, S., Jibaly, R., Tolia, V., ... Peacock, J. S. (2003). The Seroprevalence of Helicobacter pylori in a Referral Population of Children in the United States. American Journal of Gastroenterology, 98(10), 2162-2168. https://doi.org/10.1111/j.1572-0241.2003.07683.x

The Seroprevalence of Helicobacter pylori in a Referral Population of Children in the United States. / Chong, Sonny K F; Lou, Qinyuan; Zollinger, Terrell W.; Rabinowitz, Simon; Jibaly, Rima; Tolia, Vasundhara; Elitsur, Yoram; Gold, Benjamin D.; Rosenberg, Allan; Johnson, Abiodun; Elkayam, Orit; Rosenthal, Philip; Gilger, Mark; Li, B. U K; Peacock, Jeffrey S.

In: American Journal of Gastroenterology, Vol. 98, No. 10, 10.2003, p. 2162-2168.

Research output: Contribution to journalArticle

Chong, SKF, Lou, Q, Zollinger, TW, Rabinowitz, S, Jibaly, R, Tolia, V, Elitsur, Y, Gold, BD, Rosenberg, A, Johnson, A, Elkayam, O, Rosenthal, P, Gilger, M, Li, BUK & Peacock, JS 2003, 'The Seroprevalence of Helicobacter pylori in a Referral Population of Children in the United States', American Journal of Gastroenterology, vol. 98, no. 10, pp. 2162-2168. https://doi.org/10.1111/j.1572-0241.2003.07683.x
Chong, Sonny K F ; Lou, Qinyuan ; Zollinger, Terrell W. ; Rabinowitz, Simon ; Jibaly, Rima ; Tolia, Vasundhara ; Elitsur, Yoram ; Gold, Benjamin D. ; Rosenberg, Allan ; Johnson, Abiodun ; Elkayam, Orit ; Rosenthal, Philip ; Gilger, Mark ; Li, B. U K ; Peacock, Jeffrey S. / The Seroprevalence of Helicobacter pylori in a Referral Population of Children in the United States. In: American Journal of Gastroenterology. 2003 ; Vol. 98, No. 10. pp. 2162-2168.
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abstract = "OBJECTIVES: The purpose of this study was to determine the prevalence of serum antibodies directed against Helicobacter pylori (H. pylori) in children referred to children's hospitals or medical centers throughout the United States. METHODS: This multisite cross-sectional prospective study involved 992 children from 12 states using a validated anti-H. pylori IgG enzyme immunoassay. The children were recruited into two groups: those without any GI complaints (non-GI referral, n = 619) and those who were referred for endoscopy because of abdominal pain (GI referral, n = 373). RESULTS: GI referral children had a higher rate of seropositivity (22.5{\%}) than non-GI referral children (14.1{\%}) from the same geographic regions. In both groups, older children were more likely to be seropositive for H. pylori, as were nonwhite children and those with lower socioeconomic status. H. pylori seropositivity rates were higher in GI referral children with four or more household members (relative risk [RR] = 1.47; CI 1.01-2.14). Multivariate analysis controlling for age, ethnicity, and household income, showed that presence of GI symptoms were associated with a nearly 2-fold risk for H. pylori seropositivity (odds ratio = 1.77, CI 1.27-2.47). Epigastric pain (RR = 2.21; CI = 1.33-3.66) and having three or more episodes of abdominal pain in the last 3 months (RR = 0.59, CI = 0.35-0.99) were the only specific symptoms significantly associated with H. pylori seropositivity. CONCLUSIONS: The H. pylori seropositivity rate of GI referral children with symptoms of abdominal pain was significantly higher. H. pylori infection in early childhood was found to be associated primarily with the child's household size and socioeconomic status.",
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AU - Rabinowitz, Simon

AU - Jibaly, Rima

AU - Tolia, Vasundhara

AU - Elitsur, Yoram

AU - Gold, Benjamin D.

AU - Rosenberg, Allan

AU - Johnson, Abiodun

AU - Elkayam, Orit

AU - Rosenthal, Philip

AU - Gilger, Mark

AU - Li, B. U K

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N2 - OBJECTIVES: The purpose of this study was to determine the prevalence of serum antibodies directed against Helicobacter pylori (H. pylori) in children referred to children's hospitals or medical centers throughout the United States. METHODS: This multisite cross-sectional prospective study involved 992 children from 12 states using a validated anti-H. pylori IgG enzyme immunoassay. The children were recruited into two groups: those without any GI complaints (non-GI referral, n = 619) and those who were referred for endoscopy because of abdominal pain (GI referral, n = 373). RESULTS: GI referral children had a higher rate of seropositivity (22.5%) than non-GI referral children (14.1%) from the same geographic regions. In both groups, older children were more likely to be seropositive for H. pylori, as were nonwhite children and those with lower socioeconomic status. H. pylori seropositivity rates were higher in GI referral children with four or more household members (relative risk [RR] = 1.47; CI 1.01-2.14). Multivariate analysis controlling for age, ethnicity, and household income, showed that presence of GI symptoms were associated with a nearly 2-fold risk for H. pylori seropositivity (odds ratio = 1.77, CI 1.27-2.47). Epigastric pain (RR = 2.21; CI = 1.33-3.66) and having three or more episodes of abdominal pain in the last 3 months (RR = 0.59, CI = 0.35-0.99) were the only specific symptoms significantly associated with H. pylori seropositivity. CONCLUSIONS: The H. pylori seropositivity rate of GI referral children with symptoms of abdominal pain was significantly higher. H. pylori infection in early childhood was found to be associated primarily with the child's household size and socioeconomic status.

AB - OBJECTIVES: The purpose of this study was to determine the prevalence of serum antibodies directed against Helicobacter pylori (H. pylori) in children referred to children's hospitals or medical centers throughout the United States. METHODS: This multisite cross-sectional prospective study involved 992 children from 12 states using a validated anti-H. pylori IgG enzyme immunoassay. The children were recruited into two groups: those without any GI complaints (non-GI referral, n = 619) and those who were referred for endoscopy because of abdominal pain (GI referral, n = 373). RESULTS: GI referral children had a higher rate of seropositivity (22.5%) than non-GI referral children (14.1%) from the same geographic regions. In both groups, older children were more likely to be seropositive for H. pylori, as were nonwhite children and those with lower socioeconomic status. H. pylori seropositivity rates were higher in GI referral children with four or more household members (relative risk [RR] = 1.47; CI 1.01-2.14). Multivariate analysis controlling for age, ethnicity, and household income, showed that presence of GI symptoms were associated with a nearly 2-fold risk for H. pylori seropositivity (odds ratio = 1.77, CI 1.27-2.47). Epigastric pain (RR = 2.21; CI = 1.33-3.66) and having three or more episodes of abdominal pain in the last 3 months (RR = 0.59, CI = 0.35-0.99) were the only specific symptoms significantly associated with H. pylori seropositivity. CONCLUSIONS: The H. pylori seropositivity rate of GI referral children with symptoms of abdominal pain was significantly higher. H. pylori infection in early childhood was found to be associated primarily with the child's household size and socioeconomic status.

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