The significance of non-sustained hypotension in emergency department patients with sepsis

Michael R. Marchick, Jeffrey Kline, Alan E. Jones

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Objective: Few studies have documented the incidence and significance of non-sustained hypotension in emergency department (ED) patients with sepsis. We hypothesized that ED non-sustained hypotension increases risk of in-hospital mortality in patients with sepsis. Methods: Secondary analysis of a prospective cohort study. ED patients aged >17 years admitted to the hospital with explicitly defined sepsis were prospectively identified. Inclusion criteria: Evidence of systemic inflammation (>1 criteria) and suspicion for infection. Patients with overt shock were excluded. The primary outcome was in-hospital mortality. Results: Seven hundred patients with sepsis were enrolled, including 150 (21%) with non-sustained hypotension. The primary outcome of in-hospital mortality was present in 10% (15/150) of patients with non-sustained hypotension compared with 3.6% (20/550) of patients with no hypotension. The presence of non-sustained hypotension resulted in three times the risk of mortality than no hypotension (risk ratio = 2.8, 95% CI 1.5-5.2). Patients with a lowest systolic blood pressure

Original languageEnglish (US)
Pages (from-to)1261-1264
Number of pages4
JournalIntensive Care Medicine
Volume35
Issue number7
DOIs
StatePublished - Jul 2009
Externally publishedYes

Fingerprint

Hypotension
Hospital Emergency Service
Sepsis
Hospital Mortality
Shock
Cohort Studies
Odds Ratio
Prospective Studies
Blood Pressure
Inflammation
Mortality
Incidence
Infection

Keywords

  • Emergency medicine
  • Hypotension
  • Mortality
  • Sepsis
  • Shock

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

The significance of non-sustained hypotension in emergency department patients with sepsis. / Marchick, Michael R.; Kline, Jeffrey; Jones, Alan E.

In: Intensive Care Medicine, Vol. 35, No. 7, 07.2009, p. 1261-1264.

Research output: Contribution to journalArticle

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