The spectrum of morphology in non-neoplastic prostate including cancer mimics

Rodolfo Montironi, Marina Scarpelli, Roberta Mazzucchelli, Liang Cheng, Antonio Lopez-Beltran

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The spectrum of morphology in non-neoplastic prostate includes lesions of prostatic epithelial origin, the most common being atrophy, including partial atrophy, adenosis (atypical adenomatous hyperplasia), basal cell hyperplasia and crowded benign glands, as well as those of non-prostatic origin, such as seminal vesicle epithelium. These lesions often mimic lower-grade prostatic adenocarcinoma whereas others, such as granulomatous prostatitis, for example, are in the differential diagnosis of adenocarcinoma, Gleason grades 4 or 5. Diagnostic awareness of the salient histomorphological and relevant immunohistochemical features of these prostatic pseudoneoplasms is critical to avoid rendering false positive diagnoses of malignancy.

Original languageEnglish
Pages (from-to)41-58
Number of pages18
JournalHistopathology
Volume60
Issue number1
DOIs
StatePublished - Jan 2012

Fingerprint

Atrophy
Hyperplasia
Prostatic Neoplasms
Adenocarcinoma
Prostatitis
Seminal Vesicles
Prostate
Differential Diagnosis
Epithelium
Neoplasms

Keywords

  • Adenosis (atypical adenomatous hyperplasia)
  • Atrophy
  • Basal cell hyperplasia
  • Clear cell cribriform hyperplasia
  • Prostate cancer
  • Prostate cancer mimics

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

Cite this

The spectrum of morphology in non-neoplastic prostate including cancer mimics. / Montironi, Rodolfo; Scarpelli, Marina; Mazzucchelli, Roberta; Cheng, Liang; Lopez-Beltran, Antonio.

In: Histopathology, Vol. 60, No. 1, 01.2012, p. 41-58.

Research output: Contribution to journalArticle

Montironi, R, Scarpelli, M, Mazzucchelli, R, Cheng, L & Lopez-Beltran, A 2012, 'The spectrum of morphology in non-neoplastic prostate including cancer mimics', Histopathology, vol. 60, no. 1, pp. 41-58. https://doi.org/10.1111/j.1365-2559.2011.04000.x
Montironi, Rodolfo ; Scarpelli, Marina ; Mazzucchelli, Roberta ; Cheng, Liang ; Lopez-Beltran, Antonio. / The spectrum of morphology in non-neoplastic prostate including cancer mimics. In: Histopathology. 2012 ; Vol. 60, No. 1. pp. 41-58.
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