The spectrum of morphology in non-neoplastic prostate including cancer mimics

Rodolfo Montironi, Marina Scarpelli, Roberta Mazzucchelli, Liang Cheng, Antonio Lopez-Beltran

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

The spectrum of morphology in non-neoplastic prostate includes lesions of prostatic epithelial origin, the most common being atrophy, including partial atrophy, adenosis (atypical adenomatous hyperplasia), basal cell hyperplasia and crowded benign glands, as well as those of non-prostatic origin, such as seminal vesicle epithelium. These lesions often mimic lower-grade prostatic adenocarcinoma whereas others, such as granulomatous prostatitis, for example, are in the differential diagnosis of adenocarcinoma, Gleason grades 4 or 5. Diagnostic awareness of the salient histomorphological and relevant immunohistochemical features of these prostatic pseudoneoplasms is critical to avoid rendering false positive diagnoses of malignancy.

Original languageEnglish (US)
Pages (from-to)41-58
Number of pages18
JournalHistopathology
Volume60
Issue number1
DOIs
StatePublished - Jan 1 2012

Keywords

  • Adenosis (atypical adenomatous hyperplasia)
  • Atrophy
  • Basal cell hyperplasia
  • Clear cell cribriform hyperplasia
  • Prostate cancer
  • Prostate cancer mimics

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

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