Phosphoglucose isomerase (PGI) is a workhorse enzyme of carbohydrate metabolism that interconverts glucose 6-phosphate and fructose 6-phosphate. Outside the cell, however, the protein appears to function as a cytokine. A crystal structure of human PGI bound with 5-phosphoarabinonate, a strong inhibitor that mimics the cis-enediol(ate) intermediate of the reaction, has been determined at 2.5 Å resolution. The structure helps to confirm the assignment of Glu357 as the base catalyst in the isomerase reaction.
|Original language||English (US)|
|Number of pages||3|
|Journal||Acta Crystallographica - Section D Biological Crystallography|
|State||Published - Jun 1 2003|
ASJC Scopus subject areas
- Structural Biology