The synergistic interactions of oleoyl-lysophosphatidic acid in platelet aggregation

Desmond Nugent, Jerome L. Belinson, Yan Xu

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We have studied the ability of oleoyllysophosphatidic acid (O-LPA) to induce a synergistic platelet aggregatory response with the following agents: ADP, noradrenaline (NA), thrombin receptor agonist peptide (TRAP1-6), arachidonic acid (AA), phorbol 12-myristate 13-acetate (PMA), Ca2+ ionophore A23,187 and sodium fluoride (NaF). O-LPA mediated synergism with the aggregating agents (ADP, noradrenaline and TRAP1-6) which mediate their aggregatory responses through platelet membrane-bound receptors. Arachidonic acid also falls into the above group, as the platelet aggregation mediated by this fatty acid is through the synthesis of thromboxane A, which binds to its own platelet cell membrane receptor. O-LPA reduced the response time of platelets to both PMA and the Ca2+ ionophore A23,187 with minimum effect on the total percentage aggregation. Finally, O-LPA appeared not to synergise with NaF.

Original languageEnglish (US)
Pages (from-to)435-441
Number of pages7
JournalMedical Science Research
Volume27
Issue number7
StatePublished - Aug 28 1999

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Keywords

  • ADP
  • Arachidonic acid
  • Ionophore A23,187
  • Lysophosphatidic acid
  • Noradrenaline phorbol 12-myristate 13-acetate
  • Platelet aggregation
  • Sodium fluoride
  • Thrombin receptor agonist peptide

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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