The Systemic Synuclein Sampling Study: Toward a biomarker for Parkinson's disease

Naomi P. Visanji, Brit Mollenhauer, Thomas G. Beach, Charles H. Adler, Christopher S. Coffey, Catherine M. Kopil, Kuldip D. Dave, Tatiana Foroud, Lana Chahine, Danna Jennings

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The search for a biomarker for Parkinson's disease (PD) has led to a surge in literature describing peripheral α-synuclein (aSyn) in both biofluids and biopsy/autopsy tissues. Despite encouraging results, attempts to capitalize on this promise have fallen woefully short. The Systemic Synuclein Sampling Study (S4) is uniquely designed to identify a reproducible diagnostic and progression biomarker for PD. S4 will evaluate aSyn in multiple tissues and biofluids within the same subject and across the disease spectrum to identify the optimal biomarker source and provide vital information on the evolution of peripheral aSyn throughout the disease. Additionally, S4 will correlate the systemic aSyn profile with an objective measure of nigrostriatal dopaminergic function furthering our understanding of the pathophysiological progression of PD.

Original languageEnglish (US)
Pages (from-to)359-368
Number of pages10
JournalBiomarkers in Medicine
Volume11
Issue number4
DOIs
StatePublished - Apr 1 2017

Fingerprint

Synucleins
Sampling Studies
Biomarkers
Parkinson Disease
Sampling
Autopsy
Tissue
Biopsy

Keywords

  • Biofluid
  • Biomarker
  • Parkinson's disease
  • Tissue
  • α-synuclein

ASJC Scopus subject areas

  • Drug Discovery
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Visanji, N. P., Mollenhauer, B., Beach, T. G., Adler, C. H., Coffey, C. S., Kopil, C. M., ... Jennings, D. (2017). The Systemic Synuclein Sampling Study: Toward a biomarker for Parkinson's disease. Biomarkers in Medicine, 11(4), 359-368. https://doi.org/10.2217/bmm-2016-0366

The Systemic Synuclein Sampling Study : Toward a biomarker for Parkinson's disease. / Visanji, Naomi P.; Mollenhauer, Brit; Beach, Thomas G.; Adler, Charles H.; Coffey, Christopher S.; Kopil, Catherine M.; Dave, Kuldip D.; Foroud, Tatiana; Chahine, Lana; Jennings, Danna.

In: Biomarkers in Medicine, Vol. 11, No. 4, 01.04.2017, p. 359-368.

Research output: Contribution to journalArticle

Visanji, NP, Mollenhauer, B, Beach, TG, Adler, CH, Coffey, CS, Kopil, CM, Dave, KD, Foroud, T, Chahine, L & Jennings, D 2017, 'The Systemic Synuclein Sampling Study: Toward a biomarker for Parkinson's disease', Biomarkers in Medicine, vol. 11, no. 4, pp. 359-368. https://doi.org/10.2217/bmm-2016-0366
Visanji NP, Mollenhauer B, Beach TG, Adler CH, Coffey CS, Kopil CM et al. The Systemic Synuclein Sampling Study: Toward a biomarker for Parkinson's disease. Biomarkers in Medicine. 2017 Apr 1;11(4):359-368. https://doi.org/10.2217/bmm-2016-0366
Visanji, Naomi P. ; Mollenhauer, Brit ; Beach, Thomas G. ; Adler, Charles H. ; Coffey, Christopher S. ; Kopil, Catherine M. ; Dave, Kuldip D. ; Foroud, Tatiana ; Chahine, Lana ; Jennings, Danna. / The Systemic Synuclein Sampling Study : Toward a biomarker for Parkinson's disease. In: Biomarkers in Medicine. 2017 ; Vol. 11, No. 4. pp. 359-368.
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