The TFOS International Workshop on Contact Lens Discomfort: Report of the subcommittee on neurobiology

Fiona Stapleton, Carl Marfurt, Blanka Golebiowski, Mark Rosenblatt, David Bereiter, Carolyn Begley, Darlene Dartt, Juana Gallar, Carlos Belmonte, Pedram Hamrah, Mark Willcox

Research output: Contribution to journalArticle

53 Scopus citations


This report characterizes the neurobiology of the ocular surface and highlights relevant mechanisms that may underpin contact lens-related discomfort. While there is limited evidence for the mechanisms involved in contact lens-related discomfort, neurobiological mechanisms in dry eye disease, the inflammatory pathway, the effect of hyperosmolarity on ocular surface nociceptors, and subsequent sensory processing of ocular pain and discomfort have been at least partly elucidated and are presented herein to provide insight in this new arena. The stimulus to the ocular surface from a contact lens is likely to be complex and multifactorial, including components of osmolarity, solution effects, desiccation, thermal effects, inflammation, friction, and mechanical stimulation. Sensory input will arise from stimulation of the lid margin, palpebral and bulbar conjunctiva, and the cornea.

Original languageEnglish (US)
Pages (from-to)TFOS71-TFOS97
JournalInvestigative Ophthalmology and Visual Science
Issue number11
StatePublished - Sep 20 2013



  • Contact lens
  • Discomfort
  • Dry eye
  • Neurobiology

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Stapleton, F., Marfurt, C., Golebiowski, B., Rosenblatt, M., Bereiter, D., Begley, C., Dartt, D., Gallar, J., Belmonte, C., Hamrah, P., & Willcox, M. (2013). The TFOS International Workshop on Contact Lens Discomfort: Report of the subcommittee on neurobiology. Investigative Ophthalmology and Visual Science, 54(11), TFOS71-TFOS97.