Abstract
Hydrogen sulfide (H2S) has become the hot new signaling molecule that seemingly affects all organ systems and biological processes in which it has been investigated. It has also been shown to have both proinflammatory and anti-inflammatory actions and proapoptotic and anti-apoptotic effects and has even been reported to induce a hypometabolic state (suspended animation) in a few vertebrates. The exuberance over potential clinical applications of natural and synthetic H2S-"donating" compounds is understandable and a number of these function-targeted drugs have been developed and show clinical promise. However, the concentration of H2S in tissues and blood, as well as the intrinsic factors that affect these levels, has not been resolved, and it is imperative to address these points to distinguish between the physiological, pharmacological, and toxicological effects of this molecule. This review will provide an overview of H2S metabolism, a summary of many of its reported "physiological" actions, and it will discuss the recent development of a number of H2S-donating drugs that show clinical potential. It will also examine some of the misconceptions of H2S chemistry that have appeared in the literature and attempt to realign the definition of "physiological" H2S concentrations upon which much of this exuberance has been established.
| Original language | English |
|---|---|
| Journal | American Journal of Physiology - Regulatory Integrative and Comparative Physiology |
| Volume | 301 |
| Issue number | 2 |
| DOIs | |
| State | Published - Aug 2011 |
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Keywords
- Gasotransmitter
- Hydrogen sulfide-donating drugs
- Ischemia reperfusion injury
- Sulfur cycle
- Vasoactivity
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
Cite this
The therapeutic potential of hydrogen sulfide : Separating hype from hope. / Olson, Kenneth.
In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 301, No. 2, 08.2011.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The therapeutic potential of hydrogen sulfide
T2 - Separating hype from hope
AU - Olson, Kenneth
PY - 2011/8
Y1 - 2011/8
N2 - Hydrogen sulfide (H2S) has become the hot new signaling molecule that seemingly affects all organ systems and biological processes in which it has been investigated. It has also been shown to have both proinflammatory and anti-inflammatory actions and proapoptotic and anti-apoptotic effects and has even been reported to induce a hypometabolic state (suspended animation) in a few vertebrates. The exuberance over potential clinical applications of natural and synthetic H2S-"donating" compounds is understandable and a number of these function-targeted drugs have been developed and show clinical promise. However, the concentration of H2S in tissues and blood, as well as the intrinsic factors that affect these levels, has not been resolved, and it is imperative to address these points to distinguish between the physiological, pharmacological, and toxicological effects of this molecule. This review will provide an overview of H2S metabolism, a summary of many of its reported "physiological" actions, and it will discuss the recent development of a number of H2S-donating drugs that show clinical potential. It will also examine some of the misconceptions of H2S chemistry that have appeared in the literature and attempt to realign the definition of "physiological" H2S concentrations upon which much of this exuberance has been established.
AB - Hydrogen sulfide (H2S) has become the hot new signaling molecule that seemingly affects all organ systems and biological processes in which it has been investigated. It has also been shown to have both proinflammatory and anti-inflammatory actions and proapoptotic and anti-apoptotic effects and has even been reported to induce a hypometabolic state (suspended animation) in a few vertebrates. The exuberance over potential clinical applications of natural and synthetic H2S-"donating" compounds is understandable and a number of these function-targeted drugs have been developed and show clinical promise. However, the concentration of H2S in tissues and blood, as well as the intrinsic factors that affect these levels, has not been resolved, and it is imperative to address these points to distinguish between the physiological, pharmacological, and toxicological effects of this molecule. This review will provide an overview of H2S metabolism, a summary of many of its reported "physiological" actions, and it will discuss the recent development of a number of H2S-donating drugs that show clinical potential. It will also examine some of the misconceptions of H2S chemistry that have appeared in the literature and attempt to realign the definition of "physiological" H2S concentrations upon which much of this exuberance has been established.
KW - Gasotransmitter
KW - Hydrogen sulfide-donating drugs
KW - Ischemia reperfusion injury
KW - Sulfur cycle
KW - Vasoactivity
UR - http://www.scopus.com/inward/record.url?scp=79961076132&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79961076132&partnerID=8YFLogxK
U2 - 10.1152/ajpregu.00045.2011
DO - 10.1152/ajpregu.00045.2011
M3 - Article
C2 - 21543637
AN - SCOPUS:79961076132
VL - 301
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0193-1857
IS - 2
ER -