The time course of creatine kinase elevation following concentric needle EMG

R. Levin, Robert Pascuzzi, D. E. Bruns, J. C. Boyd, T. M. Toly, L. H. Phillips

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The electromyographic (EMG) exam and creatine kinase (CK) are commonly used to evaluate patients with neuromuscular diseases. Prior studies have demonstrated minimal elevation of CK following monopolar needle examination, indicating that a false positive elevation does not occur in normal individuals. We studied the magnitude and time course of CK change resulting from concentric (CNEMG) and monopolar (MNEMG) needle EMG examination on healthy volunteers. CK increased in all subjects following CNEMG and MNEMG. Statistically significant mean CK elevations over baseline were observed at 4, 8, 12, and 24 hours for CNEMG and at 12 and 24 hours for MNEMG. Maximum elevation occurred at 12 and 24 hours for both CNEMG (mean, 178% of baseline) and MNEMG (mean, 134% of baseline). CK returned to baseline by 48 to 72 hours. In 25-30% of subjects CK elevation significantly exceeded the normal range. The magnitude of CK elevation is greater and the time course more prolonged than previously reported. CK measurements should be avoided 4 to 48 hours following CNEMG because of the potential for false positive results. Measurements immediately after and at 72 hours are not affected by the CNEMG or MNEMG. The time course for CK change following MNEMG is similar to CNEMG, but the magnitude is less.

Original languageEnglish (US)
Pages (from-to)242-245
Number of pages4
JournalMuscle and Nerve
Volume10
Issue number3
DOIs
StatePublished - 1987
Externally publishedYes

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Creatine Kinase
Needles
Neuromuscular Diseases
Healthy Volunteers
Reference Values

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Levin, R., Pascuzzi, R., Bruns, D. E., Boyd, J. C., Toly, T. M., & Phillips, L. H. (1987). The time course of creatine kinase elevation following concentric needle EMG. Muscle and Nerve, 10(3), 242-245. https://doi.org/10.1002/mus.880100308

The time course of creatine kinase elevation following concentric needle EMG. / Levin, R.; Pascuzzi, Robert; Bruns, D. E.; Boyd, J. C.; Toly, T. M.; Phillips, L. H.

In: Muscle and Nerve, Vol. 10, No. 3, 1987, p. 242-245.

Research output: Contribution to journalArticle

Levin, R, Pascuzzi, R, Bruns, DE, Boyd, JC, Toly, TM & Phillips, LH 1987, 'The time course of creatine kinase elevation following concentric needle EMG', Muscle and Nerve, vol. 10, no. 3, pp. 242-245. https://doi.org/10.1002/mus.880100308
Levin, R. ; Pascuzzi, Robert ; Bruns, D. E. ; Boyd, J. C. ; Toly, T. M. ; Phillips, L. H. / The time course of creatine kinase elevation following concentric needle EMG. In: Muscle and Nerve. 1987 ; Vol. 10, No. 3. pp. 242-245.
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