The Toledo Exercise and Diet Study. Result at 26 weeks

R. F. Leighton, F. J. Repka, T. J. Birk, D. J. Lynch, J. F. Bingle, A. F. Gohara, J. Saffran, M. T. Weaver, P. M. Brewster, M. E. Walsh

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


This study was designed to test whether an exercise program is additive to diet counseling in lowering elevated blood cholesterol levels. From a screened population of 1024 subjects, we randomized 66 predominantly female subjects to two intervention groups: diet counseling and diet counseling with exercise. Subjects were selected who had elevated levels of serum low-density lipoprotein cholesterol, an average or low fitness level, and a diet high in saturated fat and cholesterol. After 26 weeks of intervention, 51 subjects exhibited significant decreases in serum levels of cholesterol, high-density lipoprotein cholesterol, triglycerides, and low-density lipoprotein cholesterol. The addition of exercise to diet counseling resulted in improved aerobic capacity, losses of body fat and weight, and further nonsignificant decreases in serum cholesterol and low-density lipoprotein cholesterol levels. Since these results differ from data acquired in individuals with normal to borderline serum cholesterol levels, further studies appear indicated in hypercholesterolemic subjects, especially in women.

Original languageEnglish (US)
Pages (from-to)1016-1020
Number of pages5
JournalArchives of Internal Medicine
Issue number5
StatePublished - Jun 5 1990

ASJC Scopus subject areas

  • Internal Medicine

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