The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality

Chaofan Li, Bibo Zhu, Young Min Son, Zheng Wang, Li Jiang, Min Xiang, Zhenqing Ye, Kathryn E. Beckermann, Yue Wu, James W. Jenkins, Peter J. Siska, Benjamin G. Vincent, Y. S. Prakash, Tobias Peikert, Brian T. Edelson, Reshma Taneja, Mark H. Kaplan, Jeffrey C. Rathmell, Haidong Dong, Taro HitosugiJie Sun

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6 Scopus citations

Abstract

The molecular regulation of CD8+ tissue-resident memory (Trm) cells and tumor-infiltrating lymphocytes (TILs) is incompletely understood. Li et al. report that the transcription factor Bhlhe40 was required for Trm cell and TIL mitochondrial fitness and epigenetic programming. They further identify an epigenetic regimen promoting TIL functional program for cancer immunotherapy.

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Keywords

  • Bhlhe40
  • PD-L1
  • Tubastatin A
  • acetate
  • epigenetic
  • metabolism
  • mitochondria
  • tissue resident memory T cell
  • tumor-infiltrating lymphocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality. / Li, Chaofan; Zhu, Bibo; Son, Young Min; Wang, Zheng; Jiang, Li; Xiang, Min; Ye, Zhenqing; Beckermann, Kathryn E.; Wu, Yue; Jenkins, James W.; Siska, Peter J.; Vincent, Benjamin G.; Prakash, Y. S.; Peikert, Tobias; Edelson, Brian T.; Taneja, Reshma; Kaplan, Mark H.; Rathmell, Jeffrey C.; Dong, Haidong; Hitosugi, Taro; Sun, Jie.

In: Immunity, Vol. 51, No. 3, 17.09.2019, p. 491-507.e7.

Research output: Contribution to journalArticle