The transcription factor Foxf1 binds to serum response factor and myocardin to regulate gene transcription in visceral smooth muscle cells

April M. Hoggatt, Ju Ryoung Kim, Vladimir Ustiyan, Xiaomeng Ren, Tanya V. Kalin, Vladimir V. Kalinichenko, B. Paul Herring

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Background:The role of Foxf1 in smooth muscle development is unknown. Results:Foxf1 binds to serum response factor and myocardin to regulate transcription and affect contractility of visceral smooth muscle cells. Conclusion:Foxf1 is required for normal development of gastrointestinal smooth muscle. Significance:Forkhead proteins interact with the SRF/myocardin axis to control the phenotype of smooth muscle cells.

Original languageEnglish (US)
Pages (from-to)28477-28487
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number40
DOIs
StatePublished - Oct 4 2013

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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