The transcription factor MEF/ELF4 regulates the quiescence of primitive hematopoietic cells

H. Daniel Lacorazza, Takeshi Yamada, Yan Liu, Yasuhiko Miyata, Mariela Sivina, Juliana Nunes, Stephen D. Nimer

Research output: Contribution to journalArticle

102 Scopus citations

Abstract

The transcriptional circuitry that regulates the quiescence of hematopoietic stem cells is largely unknown. We report that the transcription factor known as MEF (or ELF4), which is targeted by the t(X;21)(q26;q22) in acute myelogenous leukemia, regulates the proliferation of primitive hematopoietic progenitor cells at steady state, controlling their quiescence. Mef null HSCs display increased residence in G0 with reduced 5-bromodeoxyuridine incorporation in vivo and impaired cytokine-driven proliferation in vitro. Due to their increased HSC quiescence, Mef null mice are relatively resistant to the myelosuppressive effects of chemotherapy and radiation. Thus, MEF plays an important role in the decision of stem/primitive progenitor cells to divide or remain quiescent by regulating their entry to the cell cycle.

Original languageEnglish (US)
Pages (from-to)175-187
Number of pages13
JournalCancer Cell
Volume9
Issue number3
DOIs
StatePublished - Mar 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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    Lacorazza, H. D., Yamada, T., Liu, Y., Miyata, Y., Sivina, M., Nunes, J., & Nimer, S. D. (2006). The transcription factor MEF/ELF4 regulates the quiescence of primitive hematopoietic cells. Cancer Cell, 9(3), 175-187. https://doi.org/10.1016/j.ccr.2006.02.017