The transcription factor Twist1 limits T helper 17 and t follicular helper cell development by repressing the gene encoding the interleukin-6 receptor α chain

Duy Pham, Crystal C. Walline, Kristin Hollister, Alexander L. Dent, Janice S. Blum, Anthony B. Firulli, Mark H. Kaplan

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Cytokine responsiveness is a critical component of the ability of cellstorespondto the extracellular milieu. Transcription factor-mediated regulation of cytokine receptor expression is a common mode of altering responses to the external environment. We identify the transcription factor Twist1 as a component of a STAT3-induced feedback loop that controls IL-6 signals by directly repressing Il6ra. Human and mouse T cells lacking Twist1 have an increased ability to differentiate into Th17 cells. Mice with a T cell-specific deletion of Twist1 demonstrate increased Th17 and T follicular helper cell development, early onset experimental autoimmune encephalomyelitis, and increased antigen-specific antibody responses. Thus, Twist1 has a critical role in limiting both cell-mediated and humoral immunity.

Original languageEnglish (US)
Pages (from-to)27423-27433
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number38
DOIs
StatePublished - Sep 20 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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