The use and misuse of thrombolytic therapy within the veterans health administration

Salomeh Keyhani, Greg Arling, Linda S. Williams, Joseph S. Ross, Diana L. Ordin, Jennifer Myers, Gary Tyndall, Bruce Vogel, Dawn M. Bravata

Research output: Contribution to journalArticle

10 Scopus citations


Background: Within the Veterans Health Administration (VHA), approximately 6000 veterans are hospitalized with acute ischemic stroke annually. We examined the use and misuse of thrombolytic therapy with tissue plasminogen activator (tPA) in a national sample of veterans who were admitted to a VHA Medical Center (VAMC) with acute ischemic stroke. Methods: Medical record reviews were conducted on 5000 acute stroke patients who were admitted to a VAMC in 2007. Patients were defined as eligible to receive tPA if they arrived at the hospital within 3 hours of stroke symptom onset and had no contraindications to tPA. We compared eligible patients who received tPA to those who did not and examined the distribution of eligible patients across the 129 VAMCs included in this study. Results: Among the 3931 ischemic stroke patients, 174 (4.4%) were eligible for tPA. Among the 135 patients who arrived within 2 hours of symptom onset which allowed adequate time for testing and evaluation, 19 (14.1%) received tPA. An additional 11 patients received tPA but did not meet eligibility criteria. Eligible patients receiving tPA were similar to eligible patients not receiving tPA in terms of clinical conditions and time to brain imaging. Among the 30 patients that received tPA, 5 (16.6%) received the wrong dose. Among the 85 VAMCs that received 1 eligible patient, on average 2.3 patients were eligible for tPA annually. Conclusions: Relatively few eligible veterans receive thrombolysis across the VHA system. Strategies to improve thrombolysis delivery will have to account for the low annual volume of eligible stroke patients cared for at individual VAMCs.

Original languageEnglish (US)
Pages (from-to)66-73
Number of pages8
JournalMedical care
Issue number1
StatePublished - Jan 1 2012


  • health services research
  • stroke
  • thrombolytic therapy

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Fingerprint Dive into the research topics of 'The use and misuse of thrombolytic therapy within the veterans health administration'. Together they form a unique fingerprint.

  • Cite this