The use of dynamic positron emission tomography imaging for evaluating the carcinogenic progression of intestinal metaplasia to esophageal adenocarcinoma

Yan Li, Charles Woodall, John Wo, Huaiyu Zheng, Chin K. Ng, Mukunda B. Ray, Robert C. Martin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: In this study, we investigate the use of PET scanning in the carcinogenic progression of reflux esophagitis to Barrett's esophagus to high grade dysplasia to esophageal adenocarcinoma, and correlate the uptake levels of 18F-FDG related to histological changes, and the rates of proliferation and apoptosis. Methods: An established esophagoduodenal anastomsis rat model in conjunction with micro-PET scanning at 1 week, 1 month, 3 month, and 6 month after procedure was performed. Results: Increased uptake levels of 18F-FDG were observed in the esophagi after EDA procedure. The higher level of 18F-FDG uptake within esophageal epithelium was identified in intestinal metaplastic transformation and esophagoduodenal adenocarcinoma by histological examination. Conclusions: Dynamic PET scanning represents a powerful tool in analyzing morphological carcinogenic transformation non-invasively in the esophagus. 18F- FDG accumulation was a sensitive marker in reflux esophageal injury carcinogenic progression from intestinal metaplasia to EAC.

Original languageEnglish (US)
Pages (from-to)278-285
Number of pages8
JournalCancer Investigation
Volume26
Issue number3
DOIs
StatePublished - Mar 2008
Externally publishedYes

Fingerprint

Fluorodeoxyglucose F18
Metaplasia
Positron-Emission Tomography
Adenocarcinoma
Esophagus
Peptic Esophagitis
Barrett Esophagus
Gastroesophageal Reflux
Epithelium
Apoptosis
Wounds and Injuries

Keywords

  • Barrett's esophagus
  • Carcinogenic progression
  • PET imaging

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The use of dynamic positron emission tomography imaging for evaluating the carcinogenic progression of intestinal metaplasia to esophageal adenocarcinoma. / Li, Yan; Woodall, Charles; Wo, John; Zheng, Huaiyu; Ng, Chin K.; Ray, Mukunda B.; Martin, Robert C.

In: Cancer Investigation, Vol. 26, No. 3, 03.2008, p. 278-285.

Research output: Contribution to journalArticle

Li, Yan ; Woodall, Charles ; Wo, John ; Zheng, Huaiyu ; Ng, Chin K. ; Ray, Mukunda B. ; Martin, Robert C. / The use of dynamic positron emission tomography imaging for evaluating the carcinogenic progression of intestinal metaplasia to esophageal adenocarcinoma. In: Cancer Investigation. 2008 ; Vol. 26, No. 3. pp. 278-285.
@article{a9df370c28bc491b81d284f7a6bb7871,
title = "The use of dynamic positron emission tomography imaging for evaluating the carcinogenic progression of intestinal metaplasia to esophageal adenocarcinoma",
abstract = "Background: In this study, we investigate the use of PET scanning in the carcinogenic progression of reflux esophagitis to Barrett's esophagus to high grade dysplasia to esophageal adenocarcinoma, and correlate the uptake levels of 18F-FDG related to histological changes, and the rates of proliferation and apoptosis. Methods: An established esophagoduodenal anastomsis rat model in conjunction with micro-PET scanning at 1 week, 1 month, 3 month, and 6 month after procedure was performed. Results: Increased uptake levels of 18F-FDG were observed in the esophagi after EDA procedure. The higher level of 18F-FDG uptake within esophageal epithelium was identified in intestinal metaplastic transformation and esophagoduodenal adenocarcinoma by histological examination. Conclusions: Dynamic PET scanning represents a powerful tool in analyzing morphological carcinogenic transformation non-invasively in the esophagus. 18F- FDG accumulation was a sensitive marker in reflux esophageal injury carcinogenic progression from intestinal metaplasia to EAC.",
keywords = "Barrett's esophagus, Carcinogenic progression, PET imaging",
author = "Yan Li and Charles Woodall and John Wo and Huaiyu Zheng and Ng, {Chin K.} and Ray, {Mukunda B.} and Martin, {Robert C.}",
year = "2008",
month = "3",
doi = "10.1080/07357900701708401",
language = "English (US)",
volume = "26",
pages = "278--285",
journal = "Cancer Investigation",
issn = "0735-7907",
publisher = "Informa Healthcare",
number = "3",

}

TY - JOUR

T1 - The use of dynamic positron emission tomography imaging for evaluating the carcinogenic progression of intestinal metaplasia to esophageal adenocarcinoma

AU - Li, Yan

AU - Woodall, Charles

AU - Wo, John

AU - Zheng, Huaiyu

AU - Ng, Chin K.

AU - Ray, Mukunda B.

AU - Martin, Robert C.

PY - 2008/3

Y1 - 2008/3

N2 - Background: In this study, we investigate the use of PET scanning in the carcinogenic progression of reflux esophagitis to Barrett's esophagus to high grade dysplasia to esophageal adenocarcinoma, and correlate the uptake levels of 18F-FDG related to histological changes, and the rates of proliferation and apoptosis. Methods: An established esophagoduodenal anastomsis rat model in conjunction with micro-PET scanning at 1 week, 1 month, 3 month, and 6 month after procedure was performed. Results: Increased uptake levels of 18F-FDG were observed in the esophagi after EDA procedure. The higher level of 18F-FDG uptake within esophageal epithelium was identified in intestinal metaplastic transformation and esophagoduodenal adenocarcinoma by histological examination. Conclusions: Dynamic PET scanning represents a powerful tool in analyzing morphological carcinogenic transformation non-invasively in the esophagus. 18F- FDG accumulation was a sensitive marker in reflux esophageal injury carcinogenic progression from intestinal metaplasia to EAC.

AB - Background: In this study, we investigate the use of PET scanning in the carcinogenic progression of reflux esophagitis to Barrett's esophagus to high grade dysplasia to esophageal adenocarcinoma, and correlate the uptake levels of 18F-FDG related to histological changes, and the rates of proliferation and apoptosis. Methods: An established esophagoduodenal anastomsis rat model in conjunction with micro-PET scanning at 1 week, 1 month, 3 month, and 6 month after procedure was performed. Results: Increased uptake levels of 18F-FDG were observed in the esophagi after EDA procedure. The higher level of 18F-FDG uptake within esophageal epithelium was identified in intestinal metaplastic transformation and esophagoduodenal adenocarcinoma by histological examination. Conclusions: Dynamic PET scanning represents a powerful tool in analyzing morphological carcinogenic transformation non-invasively in the esophagus. 18F- FDG accumulation was a sensitive marker in reflux esophageal injury carcinogenic progression from intestinal metaplasia to EAC.

KW - Barrett's esophagus

KW - Carcinogenic progression

KW - PET imaging

UR - http://www.scopus.com/inward/record.url?scp=40149094789&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40149094789&partnerID=8YFLogxK

U2 - 10.1080/07357900701708401

DO - 10.1080/07357900701708401

M3 - Article

C2 - 18317969

AN - SCOPUS:40149094789

VL - 26

SP - 278

EP - 285

JO - Cancer Investigation

JF - Cancer Investigation

SN - 0735-7907

IS - 3

ER -