The use of dynamic positron emission tomography imaging for evaluating the carcinogenic progression of intestinal metaplasia to esophageal adenocarcinoma

Yan Li, Charles Woodall, John M. Wo, Huaiyu Zheng, Chin K. Ng, Mukunda B. Ray, Robert C. Martin

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Background: In this study, we investigate the use of PET scanning in the carcinogenic progression of reflux esophagitis to Barrett's esophagus to high grade dysplasia to esophageal adenocarcinoma, and correlate the uptake levels of 18F-FDG related to histological changes, and the rates of proliferation and apoptosis. Methods: An established esophagoduodenal anastomsis rat model in conjunction with micro-PET scanning at 1 week, 1 month, 3 month, and 6 month after procedure was performed. Results: Increased uptake levels of 18F-FDG were observed in the esophagi after EDA procedure. The higher level of 18F-FDG uptake within esophageal epithelium was identified in intestinal metaplastic transformation and esophagoduodenal adenocarcinoma by histological examination. Conclusions: Dynamic PET scanning represents a powerful tool in analyzing morphological carcinogenic transformation non-invasively in the esophagus. 18F- FDG accumulation was a sensitive marker in reflux esophageal injury carcinogenic progression from intestinal metaplasia to EAC.

Original languageEnglish (US)
Pages (from-to)278-285
Number of pages8
JournalCancer Investigation
Volume26
Issue number3
DOIs
StatePublished - Mar 1 2008
Externally publishedYes

Keywords

  • Barrett's esophagus
  • Carcinogenic progression
  • PET imaging

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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