The use of memantine in dementia with Lewy bodies

Marwan N. Sabbagh, Ann Marie Hake, Sahir Ahmed, Martin R. Farlow

Research output: Contribution to journalReview article

50 Scopus citations

Abstract

Objective: To determine the effect of memantine in the treatment of Dementia with Lewy Bodies (DLB). Background: While memantine has been used to successfully treat moderate-to-severe Alzheimer's disease (AD) and some non AD dementias, no reports are available regarding the effect of the drug on DLB. Methods: We reviewed the charts of 11 subjects with DLB by McKeith Criteria that were prospectively evaluated and treated with memantine (with or without cholinesterase inhibitors (ChEIs)) for varying lengths of time. Results: 9 of 11 DLB subjects on memantine were also on ChEIs. Seven of eleven were stable or improved with memantine while the remaining four worsened or responded adversely when exposed to the drug. No adverse effects on motor function were observed. Conclusions: Memantine can be used safely in patients with DLB, but its symptomatic effects may be variable.

Original languageEnglish (US)
Pages (from-to)285-289
Number of pages5
JournalJournal of Alzheimer's Disease
Volume7
Issue number4
DOIs
StatePublished - Jan 1 2005

Keywords

  • Dementia
  • Lewy bodies
  • Memantine

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

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