The use of tranexamic acid to reduce postoperative bleeding following cardiac surgery: A double-blind randomized trial

A. Coffey, J. Pittmam, H. Halbrook, J. Fehrenbacher, D. Beckman, D. Hormuth, D. Moorman, J. R. Edwards

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Bleeding during the first 24 hours following cardiac surgery using cardio- pulmonary bypass (CPB) is a serious complication. Attempts to modify the degree of postoperative bleeding with pharmacologic therapy have met with limited success. Tranexamic acid, a potent inhibitor of plasminogen, may decrease the amount of mediastinal bleeding following surgery utilizing CPB. We assigned 30 patients who were about to undergo cardiac surgery to a double-blind randomized trial. The treatment group received tranexamic acid, given intravenously as 10 mg/kg over 30 minutes, at the time of skin incision, followed by a 1 mg/kg/hr infusion for 12 hours. The control group received a placebo (saline) of equal volume. Measurements of shed mediastinal blood and transfused homologous blood were made at 6, 12, and 24 hours postoperatively. Mediastinal blood loss in the treatment and control groups was 382 mL versus 594 mL at 6 hours (P = 0.08), 502 mL versus 848 mL at 12 hours (P = 0.04), and 711 mL versus 1160 mL at 24 hours (P = 0.02). The mean transfusion volumes after 24 hours were 356 mL in the treatment group and 528 mL in the placebo group (P = NS). Prophylactic tranexamic acid infusion decreases mediastinal blood loss following cardiopulmonary assisted cardiac surgery.

Original languageEnglish (US)
Pages (from-to)566-568
Number of pages3
JournalAmerican Surgeon
Volume61
Issue number7
StatePublished - 1995
Externally publishedYes

Fingerprint

Tranexamic Acid
Thoracic Surgery
Hemorrhage
Placebos
Lung
Control Groups
Plasminogen
Therapeutics
Skin

ASJC Scopus subject areas

  • Surgery

Cite this

Coffey, A., Pittmam, J., Halbrook, H., Fehrenbacher, J., Beckman, D., Hormuth, D., ... Edwards, J. R. (1995). The use of tranexamic acid to reduce postoperative bleeding following cardiac surgery: A double-blind randomized trial. American Surgeon, 61(7), 566-568.

The use of tranexamic acid to reduce postoperative bleeding following cardiac surgery : A double-blind randomized trial. / Coffey, A.; Pittmam, J.; Halbrook, H.; Fehrenbacher, J.; Beckman, D.; Hormuth, D.; Moorman, D.; Edwards, J. R.

In: American Surgeon, Vol. 61, No. 7, 1995, p. 566-568.

Research output: Contribution to journalArticle

Coffey, A, Pittmam, J, Halbrook, H, Fehrenbacher, J, Beckman, D, Hormuth, D, Moorman, D & Edwards, JR 1995, 'The use of tranexamic acid to reduce postoperative bleeding following cardiac surgery: A double-blind randomized trial', American Surgeon, vol. 61, no. 7, pp. 566-568.
Coffey A, Pittmam J, Halbrook H, Fehrenbacher J, Beckman D, Hormuth D et al. The use of tranexamic acid to reduce postoperative bleeding following cardiac surgery: A double-blind randomized trial. American Surgeon. 1995;61(7):566-568.
Coffey, A. ; Pittmam, J. ; Halbrook, H. ; Fehrenbacher, J. ; Beckman, D. ; Hormuth, D. ; Moorman, D. ; Edwards, J. R. / The use of tranexamic acid to reduce postoperative bleeding following cardiac surgery : A double-blind randomized trial. In: American Surgeon. 1995 ; Vol. 61, No. 7. pp. 566-568.
@article{1ed4dadc0c8547dcae1cc784bfcf5c52,
title = "The use of tranexamic acid to reduce postoperative bleeding following cardiac surgery: A double-blind randomized trial",
abstract = "Bleeding during the first 24 hours following cardiac surgery using cardio- pulmonary bypass (CPB) is a serious complication. Attempts to modify the degree of postoperative bleeding with pharmacologic therapy have met with limited success. Tranexamic acid, a potent inhibitor of plasminogen, may decrease the amount of mediastinal bleeding following surgery utilizing CPB. We assigned 30 patients who were about to undergo cardiac surgery to a double-blind randomized trial. The treatment group received tranexamic acid, given intravenously as 10 mg/kg over 30 minutes, at the time of skin incision, followed by a 1 mg/kg/hr infusion for 12 hours. The control group received a placebo (saline) of equal volume. Measurements of shed mediastinal blood and transfused homologous blood were made at 6, 12, and 24 hours postoperatively. Mediastinal blood loss in the treatment and control groups was 382 mL versus 594 mL at 6 hours (P = 0.08), 502 mL versus 848 mL at 12 hours (P = 0.04), and 711 mL versus 1160 mL at 24 hours (P = 0.02). The mean transfusion volumes after 24 hours were 356 mL in the treatment group and 528 mL in the placebo group (P = NS). Prophylactic tranexamic acid infusion decreases mediastinal blood loss following cardiopulmonary assisted cardiac surgery.",
author = "A. Coffey and J. Pittmam and H. Halbrook and J. Fehrenbacher and D. Beckman and D. Hormuth and D. Moorman and Edwards, {J. R.}",
year = "1995",
language = "English (US)",
volume = "61",
pages = "566--568",
journal = "American Surgeon",
issn = "0003-1348",
publisher = "Southeastern Surgical Congress",
number = "7",

}

TY - JOUR

T1 - The use of tranexamic acid to reduce postoperative bleeding following cardiac surgery

T2 - A double-blind randomized trial

AU - Coffey, A.

AU - Pittmam, J.

AU - Halbrook, H.

AU - Fehrenbacher, J.

AU - Beckman, D.

AU - Hormuth, D.

AU - Moorman, D.

AU - Edwards, J. R.

PY - 1995

Y1 - 1995

N2 - Bleeding during the first 24 hours following cardiac surgery using cardio- pulmonary bypass (CPB) is a serious complication. Attempts to modify the degree of postoperative bleeding with pharmacologic therapy have met with limited success. Tranexamic acid, a potent inhibitor of plasminogen, may decrease the amount of mediastinal bleeding following surgery utilizing CPB. We assigned 30 patients who were about to undergo cardiac surgery to a double-blind randomized trial. The treatment group received tranexamic acid, given intravenously as 10 mg/kg over 30 minutes, at the time of skin incision, followed by a 1 mg/kg/hr infusion for 12 hours. The control group received a placebo (saline) of equal volume. Measurements of shed mediastinal blood and transfused homologous blood were made at 6, 12, and 24 hours postoperatively. Mediastinal blood loss in the treatment and control groups was 382 mL versus 594 mL at 6 hours (P = 0.08), 502 mL versus 848 mL at 12 hours (P = 0.04), and 711 mL versus 1160 mL at 24 hours (P = 0.02). The mean transfusion volumes after 24 hours were 356 mL in the treatment group and 528 mL in the placebo group (P = NS). Prophylactic tranexamic acid infusion decreases mediastinal blood loss following cardiopulmonary assisted cardiac surgery.

AB - Bleeding during the first 24 hours following cardiac surgery using cardio- pulmonary bypass (CPB) is a serious complication. Attempts to modify the degree of postoperative bleeding with pharmacologic therapy have met with limited success. Tranexamic acid, a potent inhibitor of plasminogen, may decrease the amount of mediastinal bleeding following surgery utilizing CPB. We assigned 30 patients who were about to undergo cardiac surgery to a double-blind randomized trial. The treatment group received tranexamic acid, given intravenously as 10 mg/kg over 30 minutes, at the time of skin incision, followed by a 1 mg/kg/hr infusion for 12 hours. The control group received a placebo (saline) of equal volume. Measurements of shed mediastinal blood and transfused homologous blood were made at 6, 12, and 24 hours postoperatively. Mediastinal blood loss in the treatment and control groups was 382 mL versus 594 mL at 6 hours (P = 0.08), 502 mL versus 848 mL at 12 hours (P = 0.04), and 711 mL versus 1160 mL at 24 hours (P = 0.02). The mean transfusion volumes after 24 hours were 356 mL in the treatment group and 528 mL in the placebo group (P = NS). Prophylactic tranexamic acid infusion decreases mediastinal blood loss following cardiopulmonary assisted cardiac surgery.

UR - http://www.scopus.com/inward/record.url?scp=0029072782&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029072782&partnerID=8YFLogxK

M3 - Article

C2 - 7793735

AN - SCOPUS:0029072782

VL - 61

SP - 566

EP - 568

JO - American Surgeon

JF - American Surgeon

SN - 0003-1348

IS - 7

ER -