The utility of clinical and radiographic features in the diagnosis of cytomegalovirus central nervous system disease in AIDS patients

Don G. Burke, Debra G.B. Leonard, Thomas F. Imperiale, Hernan Valdez, Boris Karaman, Elizabeth Shick, Robert C. Kalayjian

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Background: Polymerase chain reaction (PCR) assays of cerebrospinal fluid (CSF) for cytomegalovirus (CMV) DNA have facilitated the diagnosis of CMV-associated central nervous system disease in AIDS patients. We attempt to correlate clinical and radiographic features that are associated with CMV PCR-positivity in CSF from AIDS patients with neurologic disease. Methods and Results: A retrospective case controlled comparison was made of CMV PCR- positive and PCR-negative patients. Results: CMV PCR-positive patients were significantly more likely to have nystagmus, prior CMV retinitis, and CSF protein levels >90 mg/dL. Of patients with 0, 1, and ≥2 of these features, 5.6%, 55.2%, and 88.9%, respectively, were PCR-positive. Ependymal enhancement was present by magnetic resonance imaging in 9 of 12 PCR- positive, and in 8 of 30 PCR-negative patients. Conclusion: These clinical and radiographic features may serve as useful adjuncts toward the establishment of the diagnosis of CMV-associated neurologic disease in AIDS patients.

Original languageEnglish (US)
Pages (from-to)37-43
Number of pages7
JournalMolecular Diagnosis
Volume4
Issue number1
DOIs
StatePublished - Jan 1 1999

Keywords

  • Cerebrospinal fluid
  • Opportunistic infection
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Medicine(all)

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