The utility of clinical and radiographic features in the diagnosis of cytomegalovirus central nervous system disease in AIDS patients

Don G. Burke, Debra G B Leonard, Thomas Imperiale, Hernan Valdez, Boris Karaman, Elizabeth Shick, Robert C. Kalayjian

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Polymerase chain reaction (PCR) assays of cerebrospinal fluid (CSF) for cytomegalovirus (CMV) DNA have facilitated the diagnosis of CMV-associated central nervous system disease in AIDS patients. We attempt to correlate clinical and radiographic features that are associated with CMV PCR-positivity in CSF from AIDS patients with neurologic disease. Methods and Results: A retrospective case controlled comparison was made of CMV PCR- positive and PCR-negative patients. Results: CMV PCR-positive patients were significantly more likely to have nystagmus, prior CMV retinitis, and CSF protein levels >90 mg/dL. Of patients with 0, 1, and ≥2 of these features, 5.6%, 55.2%, and 88.9%, respectively, were PCR-positive. Ependymal enhancement was present by magnetic resonance imaging in 9 of 12 PCR- positive, and in 8 of 30 PCR-negative patients. Conclusion: These clinical and radiographic features may serve as useful adjuncts toward the establishment of the diagnosis of CMV-associated neurologic disease in AIDS patients.

Original languageEnglish
Pages (from-to)37-43
Number of pages7
JournalMolecular Diagnosis
Volume4
Issue number1
DOIs
StatePublished - 1999

Fingerprint

Central Nervous System Diseases
Cytomegalovirus
Acquired Immunodeficiency Syndrome
Polymerase Chain Reaction
Nervous System Diseases
Cerebrospinal Fluid
Cytomegalovirus Retinitis
Cerebrospinal Fluid Proteins
Magnetic Resonance Imaging
DNA

Keywords

  • Cerebrospinal fluid
  • Opportunistic infection
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The utility of clinical and radiographic features in the diagnosis of cytomegalovirus central nervous system disease in AIDS patients. / Burke, Don G.; Leonard, Debra G B; Imperiale, Thomas; Valdez, Hernan; Karaman, Boris; Shick, Elizabeth; Kalayjian, Robert C.

In: Molecular Diagnosis, Vol. 4, No. 1, 1999, p. 37-43.

Research output: Contribution to journalArticle

Burke, Don G. ; Leonard, Debra G B ; Imperiale, Thomas ; Valdez, Hernan ; Karaman, Boris ; Shick, Elizabeth ; Kalayjian, Robert C. / The utility of clinical and radiographic features in the diagnosis of cytomegalovirus central nervous system disease in AIDS patients. In: Molecular Diagnosis. 1999 ; Vol. 4, No. 1. pp. 37-43.
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