The vaccinia virus N1L protein influences cytokine secretion in vitro after infection

Zhouning Zhang, Melissa Rose Abrahams, Lawrence A. Hunt, Jill Suttles, William Marshall, Debomoy K. Lahiri, Girish J. Kotwal

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The vaccinia virus N1L ORF encodes a protein that enhances virulence and replication of the virus by an unknown mechanism. It has been studied for its ability to enhance viral replication and dissemination in the brain and more recently has been linked to an immunomodulatory role in which it inhibits the activation of cytokine transcription activators in Toll-like receptor signaling pathways after pathogen recognition. The effect of N1L on the release of cytokines from human primary monocytes was investigated. Secretion of the proinflammatory, antiviral cytokines TNF-α, IL-1β, IFN-α, IFN-β, and the anti-inflammatory cytokine IL-10 was found to be inhibited by the presence of the N1L protein.

Original languageEnglish (US)
Pages (from-to)69-86
Number of pages18
JournalAnnals of the New York Academy of Sciences
Volume1056
DOIs
StatePublished - Jan 1 2005

    Fingerprint

Keywords

  • Cytokines
  • IFN-β
  • N1L ORF
  • NF-κB
  • TNF

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this