The Value of Diffusion-Weighted Imaging in Characterizing Focal Liver Masses

Kumaresan Sandrasegaran, Fatih M. Akisik, Chen Lin, Bilal Tahir, Janaki Rajan, Alex M. Aisen

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Rationale and Objectives: To determine if focal liver masses could be differentiated as benign or malignant on the basis of diffusion-weighted imaging (DWI). Methods and Materials: A total of 104 patients with focal liver masses were scanned using 1.5 T magnetic resonance imaging (MRI). DWI was performed with b values of 0, 50, and 400 s/mm2. Of these, 76 patients had lesions larger than 2 cm diameter, radiologic or pathologic characterization of the lesion, and diagnostic quality DWI. The apparent diffusion coefficient (ADC) of the largest liver lesion was measured. The liver masses were diagnosed on histology or had characteristic computed tomography/MRI findings and follow up of more than 6 months. The analyzed lesions were hemangioma (n = 17), cysts (n = 5), hepatocellular cancer (HCC) (n = 41), adenoma (n = 3), focal nodular hyperplasia (FNH) (n = 6), and metastases (n = 4). Results: The mean (standard deviation) ADC values (10-5 mm2/second) of hemangiomas, cysts, FNH, and HCC were 156.8 (54.1), 190.2 (43.0), 130.1 (81.9), and 107.6 (32.7). The ADC of cysts and hemangiomas were significantly higher than that of other lesions (P = .0003, t-test). There was no significant difference between ADC values of solid, benign liver lesions (FNH, adenoma) and malignant lesions (HCC, metastases) (P = .62). Conclusion: Solid liver lesions have a lower ADC than cysts and hemangiomas. However, there is no significant difference in ADC between solid benign and malignant lesions. DWI appears to have only minimal additional value over currently used MRI sequences in characterizing liver masses.

Original languageEnglish (US)
Pages (from-to)1208-1214
Number of pages7
JournalAcademic radiology
Volume16
Issue number10
DOIs
StatePublished - Oct 1 2009

Fingerprint

Liver
Focal Nodular Hyperplasia
Hemangioma
Cysts
Liver Neoplasms
Magnetic Resonance Imaging
Neoplasm Metastasis
Adenoma
Histology
Adenocarcinoma
Tomography

Keywords

  • Diffusion-weighted MRI
  • hemangioma
  • hepatocellular cancer
  • liver neoplasm

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

The Value of Diffusion-Weighted Imaging in Characterizing Focal Liver Masses. / Sandrasegaran, Kumaresan; Akisik, Fatih M.; Lin, Chen; Tahir, Bilal; Rajan, Janaki; Aisen, Alex M.

In: Academic radiology, Vol. 16, No. 10, 01.10.2009, p. 1208-1214.

Research output: Contribution to journalArticle

Sandrasegaran, Kumaresan ; Akisik, Fatih M. ; Lin, Chen ; Tahir, Bilal ; Rajan, Janaki ; Aisen, Alex M. / The Value of Diffusion-Weighted Imaging in Characterizing Focal Liver Masses. In: Academic radiology. 2009 ; Vol. 16, No. 10. pp. 1208-1214.
@article{a185fc6319d44e99913b5692ecc0eb74,
title = "The Value of Diffusion-Weighted Imaging in Characterizing Focal Liver Masses",
abstract = "Rationale and Objectives: To determine if focal liver masses could be differentiated as benign or malignant on the basis of diffusion-weighted imaging (DWI). Methods and Materials: A total of 104 patients with focal liver masses were scanned using 1.5 T magnetic resonance imaging (MRI). DWI was performed with b values of 0, 50, and 400 s/mm2. Of these, 76 patients had lesions larger than 2 cm diameter, radiologic or pathologic characterization of the lesion, and diagnostic quality DWI. The apparent diffusion coefficient (ADC) of the largest liver lesion was measured. The liver masses were diagnosed on histology or had characteristic computed tomography/MRI findings and follow up of more than 6 months. The analyzed lesions were hemangioma (n = 17), cysts (n = 5), hepatocellular cancer (HCC) (n = 41), adenoma (n = 3), focal nodular hyperplasia (FNH) (n = 6), and metastases (n = 4). Results: The mean (standard deviation) ADC values (10-5 mm2/second) of hemangiomas, cysts, FNH, and HCC were 156.8 (54.1), 190.2 (43.0), 130.1 (81.9), and 107.6 (32.7). The ADC of cysts and hemangiomas were significantly higher than that of other lesions (P = .0003, t-test). There was no significant difference between ADC values of solid, benign liver lesions (FNH, adenoma) and malignant lesions (HCC, metastases) (P = .62). Conclusion: Solid liver lesions have a lower ADC than cysts and hemangiomas. However, there is no significant difference in ADC between solid benign and malignant lesions. DWI appears to have only minimal additional value over currently used MRI sequences in characterizing liver masses.",
keywords = "Diffusion-weighted MRI, hemangioma, hepatocellular cancer, liver neoplasm",
author = "Kumaresan Sandrasegaran and Akisik, {Fatih M.} and Chen Lin and Bilal Tahir and Janaki Rajan and Aisen, {Alex M.}",
year = "2009",
month = "10",
day = "1",
doi = "10.1016/j.acra.2009.05.013",
language = "English (US)",
volume = "16",
pages = "1208--1214",
journal = "Academic Radiology",
issn = "1076-6332",
publisher = "Elsevier USA",
number = "10",

}

TY - JOUR

T1 - The Value of Diffusion-Weighted Imaging in Characterizing Focal Liver Masses

AU - Sandrasegaran, Kumaresan

AU - Akisik, Fatih M.

AU - Lin, Chen

AU - Tahir, Bilal

AU - Rajan, Janaki

AU - Aisen, Alex M.

PY - 2009/10/1

Y1 - 2009/10/1

N2 - Rationale and Objectives: To determine if focal liver masses could be differentiated as benign or malignant on the basis of diffusion-weighted imaging (DWI). Methods and Materials: A total of 104 patients with focal liver masses were scanned using 1.5 T magnetic resonance imaging (MRI). DWI was performed with b values of 0, 50, and 400 s/mm2. Of these, 76 patients had lesions larger than 2 cm diameter, radiologic or pathologic characterization of the lesion, and diagnostic quality DWI. The apparent diffusion coefficient (ADC) of the largest liver lesion was measured. The liver masses were diagnosed on histology or had characteristic computed tomography/MRI findings and follow up of more than 6 months. The analyzed lesions were hemangioma (n = 17), cysts (n = 5), hepatocellular cancer (HCC) (n = 41), adenoma (n = 3), focal nodular hyperplasia (FNH) (n = 6), and metastases (n = 4). Results: The mean (standard deviation) ADC values (10-5 mm2/second) of hemangiomas, cysts, FNH, and HCC were 156.8 (54.1), 190.2 (43.0), 130.1 (81.9), and 107.6 (32.7). The ADC of cysts and hemangiomas were significantly higher than that of other lesions (P = .0003, t-test). There was no significant difference between ADC values of solid, benign liver lesions (FNH, adenoma) and malignant lesions (HCC, metastases) (P = .62). Conclusion: Solid liver lesions have a lower ADC than cysts and hemangiomas. However, there is no significant difference in ADC between solid benign and malignant lesions. DWI appears to have only minimal additional value over currently used MRI sequences in characterizing liver masses.

AB - Rationale and Objectives: To determine if focal liver masses could be differentiated as benign or malignant on the basis of diffusion-weighted imaging (DWI). Methods and Materials: A total of 104 patients with focal liver masses were scanned using 1.5 T magnetic resonance imaging (MRI). DWI was performed with b values of 0, 50, and 400 s/mm2. Of these, 76 patients had lesions larger than 2 cm diameter, radiologic or pathologic characterization of the lesion, and diagnostic quality DWI. The apparent diffusion coefficient (ADC) of the largest liver lesion was measured. The liver masses were diagnosed on histology or had characteristic computed tomography/MRI findings and follow up of more than 6 months. The analyzed lesions were hemangioma (n = 17), cysts (n = 5), hepatocellular cancer (HCC) (n = 41), adenoma (n = 3), focal nodular hyperplasia (FNH) (n = 6), and metastases (n = 4). Results: The mean (standard deviation) ADC values (10-5 mm2/second) of hemangiomas, cysts, FNH, and HCC were 156.8 (54.1), 190.2 (43.0), 130.1 (81.9), and 107.6 (32.7). The ADC of cysts and hemangiomas were significantly higher than that of other lesions (P = .0003, t-test). There was no significant difference between ADC values of solid, benign liver lesions (FNH, adenoma) and malignant lesions (HCC, metastases) (P = .62). Conclusion: Solid liver lesions have a lower ADC than cysts and hemangiomas. However, there is no significant difference in ADC between solid benign and malignant lesions. DWI appears to have only minimal additional value over currently used MRI sequences in characterizing liver masses.

KW - Diffusion-weighted MRI

KW - hemangioma

KW - hepatocellular cancer

KW - liver neoplasm

UR - http://www.scopus.com/inward/record.url?scp=69449101091&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69449101091&partnerID=8YFLogxK

U2 - 10.1016/j.acra.2009.05.013

DO - 10.1016/j.acra.2009.05.013

M3 - Article

C2 - 19608435

AN - SCOPUS:69449101091

VL - 16

SP - 1208

EP - 1214

JO - Academic Radiology

JF - Academic Radiology

SN - 1076-6332

IS - 10

ER -