The ventilatory response to intravenous and ventriculo-cisternal theophylline

J. E. Wick, R. E. DeAtley, T. O. Oei, M. R. Glick, A. Brashear, John Baenziger, R. E. Brashear

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The stimulatory effect of theophylline on ventilation was studied in nine anesthetized dogs. Theophylline infused intravenously (10 mg/kg bolus, then 1.00 mg/kg/hr) for 210 minutes significantly increased the minute volume of ventilation (P <0.05 at 210 minutes). After a recovery period of seven to fourteen days, ventriculo-cisternal perfusion was performed with mock cerebrospinal fluid (CSF). Theophylline added to the mock CSF did not significantly change the minute ventilation. Ventriculo-cisternal perfusion utilizing mock CSF not containing theophylline combined with intravenous theophylline infusion stimulated ventilation similarly to the previous intravenous theophylline infusion. Therefore, stimulation of ventilation by theophylline appears to relate to the serum theophylline concentration and not the ventricular CSF theophylline concentration.

Original languageEnglish (US)
Pages (from-to)79-94
Number of pages16
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume41
Issue number1
StatePublished - 1983
Externally publishedYes

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Theophylline
Cerebrospinal fluid
Ventilation
Cerebrospinal Fluid
Intravenous Infusions
Perfusion
Dogs
Recovery
Serum

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

Wick, J. E., DeAtley, R. E., Oei, T. O., Glick, M. R., Brashear, A., Baenziger, J., & Brashear, R. E. (1983). The ventilatory response to intravenous and ventriculo-cisternal theophylline. Research Communications in Chemical Pathology and Pharmacology, 41(1), 79-94.

The ventilatory response to intravenous and ventriculo-cisternal theophylline. / Wick, J. E.; DeAtley, R. E.; Oei, T. O.; Glick, M. R.; Brashear, A.; Baenziger, John; Brashear, R. E.

In: Research Communications in Chemical Pathology and Pharmacology, Vol. 41, No. 1, 1983, p. 79-94.

Research output: Contribution to journalArticle

Wick, JE, DeAtley, RE, Oei, TO, Glick, MR, Brashear, A, Baenziger, J & Brashear, RE 1983, 'The ventilatory response to intravenous and ventriculo-cisternal theophylline', Research Communications in Chemical Pathology and Pharmacology, vol. 41, no. 1, pp. 79-94.
Wick, J. E. ; DeAtley, R. E. ; Oei, T. O. ; Glick, M. R. ; Brashear, A. ; Baenziger, John ; Brashear, R. E. / The ventilatory response to intravenous and ventriculo-cisternal theophylline. In: Research Communications in Chemical Pathology and Pharmacology. 1983 ; Vol. 41, No. 1. pp. 79-94.
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