The von Hippel-Lindau tumor suppressor protein

Mircea Ivan, Jr Kaelin W.G.

Research output: Contribution to journalArticle

176 Citations (Scopus)

Abstract

The von Hippel-Lindau tumor suppressor protein (pVHL) has been shown to bind directly to the alpha subunits of the heterodimeric transcription factor HIF (hypoxia inducible factor). pVHL directs the polyubiquitination and, hence, destruction of HIF in the presence of oxygen. Loss of pVHL function leads to deregulation of HIF target genes, which play critical roles in angiogenesis.

Original languageEnglish (US)
Pages (from-to)27-34
Number of pages8
JournalCurrent Opinion in Genetics and Development
Volume11
Issue number1
DOIs
StatePublished - Feb 1 2001
Externally publishedYes

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Von Hippel-Lindau Tumor Suppressor Protein
Transcription Factors
Oxygen
Genes
Hypoxia

ASJC Scopus subject areas

  • Genetics

Cite this

The von Hippel-Lindau tumor suppressor protein. / Ivan, Mircea; Kaelin W.G., Jr.

In: Current Opinion in Genetics and Development, Vol. 11, No. 1, 01.02.2001, p. 27-34.

Research output: Contribution to journalArticle

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