The von Hippel-Lindau tumor suppressor protein

Mircea Ivan, William G. Kaelin

Research output: Contribution to journalReview article

177 Scopus citations


The von Hippel-Lindau tumor suppressor protein (pVHL) has been shown to bind directly to the alpha subunits of the heterodimeric transcription factor HIF (hypoxia inducible factor). pVHL directs the polyubiquitination and, hence, destruction of HIF in the presence of oxygen. Loss of pVHL function leads to deregulation of HIF target genes, which play critical roles in angiogenesis.

Original languageEnglish (US)
Pages (from-to)27-34
Number of pages8
JournalCurrent Opinion in Genetics and Development
Issue number1
StatePublished - Feb 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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