The weaver mutant mouse as a model of nigrostriatal dysfunction

J. R. Simon, B. Ghetti

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The weaver mutant mouse has a genetic defect that results in the loss of dopamine neurons in the nigrostriatal pathway. Striatal tyrosine hydroxylase and dopamine content are reduced by 60-70%, and dopamine uptake is reduced by as much as 95%. Deficits in all three of these striatal dopamine markers are seen as early as postnatal d 3. The striatal dopamine systems in the weaver apparently have the ability to compensate for this dopamine deficit. Thus, in the weaver, in vitro resting release, as well as amphetamine-evoked fractional release of endogenous dopamine are increased. An additional change seen in the weaver striatum is an elevated serotonin content. These alterations may play an adaptive role in attempting to compensate for the dopamine loss. In summary, the weaver mutant mouse has dramatic deficits in the nigrostriatal pathway, but also seems to develop certain adaptive mechanisms in dopaminergic and other transmitter systems that may compensate functionally for the dopamine deficit. Thus, the weaver mouse provides a unique animal model for studying naturally induced neuronal degeneration that complements those models using surgical and pharmacological protocols.

Original languageEnglish (US)
Pages (from-to)183-189
Number of pages7
JournalMolecular Neurobiology
Volume9
Issue number1-3
DOIs
StatePublished - Aug 1 1994

    Fingerprint

Keywords

  • dopamine
  • mouse
  • neuronal degeneration
  • Striatum
  • weaver

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

Cite this