The World Health Organization 2016 classification of testicular non-germ cell tumours

A review and update from the International Society of Urological Pathology Testis Consultation Panel

Muhammad Idrees, Thomas Ulbright, Esther Oliva, Robert H. Young, Rodolfo Montironi, Lars Egevad, Daniel Berney, John R. Srigley, Jonathan I. Epstein, Satish K. Tickoo

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The World Health Organization (WHO) released a new tumour classification for the genitourinary system in early 2016 after consensus by pathologists with expertise in these organs. It utilized the framework of the 2004 classification, and incorporated the most up-to-date information concerning these tumours. In testicular tumours, the majority of the changes occurred in the nomenclature and classification of germ cell tumours; however, several modifications were also made for non-germ cell tumours. Among sex cord-stromal tumours, sclerosing Sertoli cell tumour (SCT) is no longer recognized as a separate entity but as a morphological variant of SCT not otherwise specified (NOS), as CTNNB1 gene mutations have been noted in both neoplasms but not in the other forms of SCT. Similarly, the lipid cell variant is not separately classified, but is considered to be a morphological variant of SCT NOS. Large-cell calcifying SCT is recognized as a distinct entity that occurs either sporadically or in association with Carney complex, with the latter patients having a distinct germline PRKAR1A gene mutation. Intratubular large-cell hyalinizing Sertoli cell neoplasia is also accepted as a separate entity linked with Peutz-Jeghers syndrome. The subcategories of 'mixed' and 'incompletely differentiated' forms of sex cord/gonadal stromal tumours have been replaced by 'mixed and unclassified sex cord-stromal tumours'. New entities introduced in the latest WHO revision include: myoid gonadal stromal tumour and 'undifferentiated gonadal tissue', a putative precursor lesion of gonadoblastoma, whereas juvenile xanthogranuloma and haemangioma are included in the miscellaneous category of tumours.

Original languageEnglish (US)
JournalHistopathology
DOIs
StateAccepted/In press - 2016

Fingerprint

Sertoli Cell Tumor
Testis
Referral and Consultation
Pathology
Sex Cord-Gonadal Stromal Tumors
Neoplasms
Carney Complex
Gonadoblastoma
Juvenile Xanthogranuloma
Peutz-Jeghers Syndrome
Urogenital System
Mutation
Sertoli Cells
Germ Cell and Embryonal Neoplasms
Testicular Neoplasms
Hemangioma
Testicular Germ Cell Tumor
Terminology
Genes
Lipids

Keywords

  • ISUP
  • Non-germ cell tumours
  • Testicular tumours
  • World Health Organization 2016 Classification

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

The World Health Organization 2016 classification of testicular non-germ cell tumours : A review and update from the International Society of Urological Pathology Testis Consultation Panel. / Idrees, Muhammad; Ulbright, Thomas; Oliva, Esther; Young, Robert H.; Montironi, Rodolfo; Egevad, Lars; Berney, Daniel; Srigley, John R.; Epstein, Jonathan I.; Tickoo, Satish K.

In: Histopathology, 2016.

Research output: Contribution to journalArticle

Idrees, Muhammad ; Ulbright, Thomas ; Oliva, Esther ; Young, Robert H. ; Montironi, Rodolfo ; Egevad, Lars ; Berney, Daniel ; Srigley, John R. ; Epstein, Jonathan I. ; Tickoo, Satish K. / The World Health Organization 2016 classification of testicular non-germ cell tumours : A review and update from the International Society of Urological Pathology Testis Consultation Panel. In: Histopathology. 2016.
@article{e8bfed118e3f4db4a128dbe41eade790,
title = "The World Health Organization 2016 classification of testicular non-germ cell tumours: A review and update from the International Society of Urological Pathology Testis Consultation Panel",
abstract = "The World Health Organization (WHO) released a new tumour classification for the genitourinary system in early 2016 after consensus by pathologists with expertise in these organs. It utilized the framework of the 2004 classification, and incorporated the most up-to-date information concerning these tumours. In testicular tumours, the majority of the changes occurred in the nomenclature and classification of germ cell tumours; however, several modifications were also made for non-germ cell tumours. Among sex cord-stromal tumours, sclerosing Sertoli cell tumour (SCT) is no longer recognized as a separate entity but as a morphological variant of SCT not otherwise specified (NOS), as CTNNB1 gene mutations have been noted in both neoplasms but not in the other forms of SCT. Similarly, the lipid cell variant is not separately classified, but is considered to be a morphological variant of SCT NOS. Large-cell calcifying SCT is recognized as a distinct entity that occurs either sporadically or in association with Carney complex, with the latter patients having a distinct germline PRKAR1A gene mutation. Intratubular large-cell hyalinizing Sertoli cell neoplasia is also accepted as a separate entity linked with Peutz-Jeghers syndrome. The subcategories of 'mixed' and 'incompletely differentiated' forms of sex cord/gonadal stromal tumours have been replaced by 'mixed and unclassified sex cord-stromal tumours'. New entities introduced in the latest WHO revision include: myoid gonadal stromal tumour and 'undifferentiated gonadal tissue', a putative precursor lesion of gonadoblastoma, whereas juvenile xanthogranuloma and haemangioma are included in the miscellaneous category of tumours.",
keywords = "ISUP, Non-germ cell tumours, Testicular tumours, World Health Organization 2016 Classification",
author = "Muhammad Idrees and Thomas Ulbright and Esther Oliva and Young, {Robert H.} and Rodolfo Montironi and Lars Egevad and Daniel Berney and Srigley, {John R.} and Epstein, {Jonathan I.} and Tickoo, {Satish K.}",
year = "2016",
doi = "10.1111/his.13115",
language = "English (US)",
journal = "Histopathology",
issn = "0309-0167",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - The World Health Organization 2016 classification of testicular non-germ cell tumours

T2 - A review and update from the International Society of Urological Pathology Testis Consultation Panel

AU - Idrees, Muhammad

AU - Ulbright, Thomas

AU - Oliva, Esther

AU - Young, Robert H.

AU - Montironi, Rodolfo

AU - Egevad, Lars

AU - Berney, Daniel

AU - Srigley, John R.

AU - Epstein, Jonathan I.

AU - Tickoo, Satish K.

PY - 2016

Y1 - 2016

N2 - The World Health Organization (WHO) released a new tumour classification for the genitourinary system in early 2016 after consensus by pathologists with expertise in these organs. It utilized the framework of the 2004 classification, and incorporated the most up-to-date information concerning these tumours. In testicular tumours, the majority of the changes occurred in the nomenclature and classification of germ cell tumours; however, several modifications were also made for non-germ cell tumours. Among sex cord-stromal tumours, sclerosing Sertoli cell tumour (SCT) is no longer recognized as a separate entity but as a morphological variant of SCT not otherwise specified (NOS), as CTNNB1 gene mutations have been noted in both neoplasms but not in the other forms of SCT. Similarly, the lipid cell variant is not separately classified, but is considered to be a morphological variant of SCT NOS. Large-cell calcifying SCT is recognized as a distinct entity that occurs either sporadically or in association with Carney complex, with the latter patients having a distinct germline PRKAR1A gene mutation. Intratubular large-cell hyalinizing Sertoli cell neoplasia is also accepted as a separate entity linked with Peutz-Jeghers syndrome. The subcategories of 'mixed' and 'incompletely differentiated' forms of sex cord/gonadal stromal tumours have been replaced by 'mixed and unclassified sex cord-stromal tumours'. New entities introduced in the latest WHO revision include: myoid gonadal stromal tumour and 'undifferentiated gonadal tissue', a putative precursor lesion of gonadoblastoma, whereas juvenile xanthogranuloma and haemangioma are included in the miscellaneous category of tumours.

AB - The World Health Organization (WHO) released a new tumour classification for the genitourinary system in early 2016 after consensus by pathologists with expertise in these organs. It utilized the framework of the 2004 classification, and incorporated the most up-to-date information concerning these tumours. In testicular tumours, the majority of the changes occurred in the nomenclature and classification of germ cell tumours; however, several modifications were also made for non-germ cell tumours. Among sex cord-stromal tumours, sclerosing Sertoli cell tumour (SCT) is no longer recognized as a separate entity but as a morphological variant of SCT not otherwise specified (NOS), as CTNNB1 gene mutations have been noted in both neoplasms but not in the other forms of SCT. Similarly, the lipid cell variant is not separately classified, but is considered to be a morphological variant of SCT NOS. Large-cell calcifying SCT is recognized as a distinct entity that occurs either sporadically or in association with Carney complex, with the latter patients having a distinct germline PRKAR1A gene mutation. Intratubular large-cell hyalinizing Sertoli cell neoplasia is also accepted as a separate entity linked with Peutz-Jeghers syndrome. The subcategories of 'mixed' and 'incompletely differentiated' forms of sex cord/gonadal stromal tumours have been replaced by 'mixed and unclassified sex cord-stromal tumours'. New entities introduced in the latest WHO revision include: myoid gonadal stromal tumour and 'undifferentiated gonadal tissue', a putative precursor lesion of gonadoblastoma, whereas juvenile xanthogranuloma and haemangioma are included in the miscellaneous category of tumours.

KW - ISUP

KW - Non-germ cell tumours

KW - Testicular tumours

KW - World Health Organization 2016 Classification

UR - http://www.scopus.com/inward/record.url?scp=85007107179&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85007107179&partnerID=8YFLogxK

U2 - 10.1111/his.13115

DO - 10.1111/his.13115

M3 - Article

JO - Histopathology

JF - Histopathology

SN - 0309-0167

ER -