The yeast cyclins Pc16p and Pc17p are involved in the control of glycogen storage by the cyclin-dependent protein kinase Pho85p

Zhong Wang, Wayne A. Wilson, Marie A. Fujino, Peter J. Roach

Research output: Contribution to journalArticle

26 Scopus citations


Pho85p is a yeast cyclin-dependent protein kinase (Cdk) that can interact with 10 cyclins (Pcls) to form multiple protein kinases. The functions of most of the Pcls, including Pc16p and Pc17p, are poorly defined. We report here that Pc16p and Pc17p are involved in the metabolism of the branched storage polysaccharide glycogen under certain conditions and deletion of PCL6 and PCL7 restores glycogen accumulation to a snf1 pcl8 pcl10 triple mutant, paradoxically activating both glycogen synthase and phosphorylase. Pho85p thus affects glycogen accumulation through multiple Cdks composed of different cyclin partners.

Original languageEnglish (US)
Pages (from-to)277-280
Number of pages4
JournalFEBS Letters
Issue number3
StatePublished - Oct 12 2001



  • Cyclin-dependent protein kinase
  • Glycogen
  • PCL6
  • PCL7
  • PHO85
  • SNF1

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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