Theoretical and experimental evidence for hysteresis in cell proliferation.

Shaochun Bai, David Goodrich, C. Dennis Thron, Edwin Tecarro, Mandri Obeyesekere

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We propose a mathematical model for the regulation of the G1-phase of the mammalian cell cycle taking into account interactions of cyclin D/cdk4, cyclin E/cdk2, Rb and E2F. Mathematical analysis of this model predicts that a change in the proliferative status in response to a change in concentrations of serum growth factors will exhibit the property of hysteresis: the concentration of growth factors required to induce proliferation is higher than the concentration required to maintain proliferation. We experimentally confirmed this prediction in mouse embryonic fibroblasts in vitro. In agreement with the mathematical model, this indicates that changes in proliferative mode caused by small changes in concentrations of growth factors are not easily reversible. Based on this study, we discuss the importance of proliferation hysteresis for cell cycle regulation.

Original languageEnglish (US)
Pages (from-to)46-52
Number of pages7
JournalCell Cycle
Volume2
Issue number1
StatePublished - Jan 2003
Externally publishedYes

Fingerprint

Cell proliferation
Hysteresis
Intercellular Signaling Peptides and Proteins
Theoretical Models
Cell Proliferation
Cell Cycle
Cells
Mathematical models
Cyclin D
Cyclin E
G1 Phase
Fibroblasts
Serum

ASJC Scopus subject areas

  • Cell Biology
  • Biochemistry
  • Molecular Biology

Cite this

Bai, S., Goodrich, D., Thron, C. D., Tecarro, E., & Obeyesekere, M. (2003). Theoretical and experimental evidence for hysteresis in cell proliferation. Cell Cycle, 2(1), 46-52.

Theoretical and experimental evidence for hysteresis in cell proliferation. / Bai, Shaochun; Goodrich, David; Thron, C. Dennis; Tecarro, Edwin; Obeyesekere, Mandri.

In: Cell Cycle, Vol. 2, No. 1, 01.2003, p. 46-52.

Research output: Contribution to journalArticle

Bai, S, Goodrich, D, Thron, CD, Tecarro, E & Obeyesekere, M 2003, 'Theoretical and experimental evidence for hysteresis in cell proliferation.', Cell Cycle, vol. 2, no. 1, pp. 46-52.
Bai S, Goodrich D, Thron CD, Tecarro E, Obeyesekere M. Theoretical and experimental evidence for hysteresis in cell proliferation. Cell Cycle. 2003 Jan;2(1):46-52.
Bai, Shaochun ; Goodrich, David ; Thron, C. Dennis ; Tecarro, Edwin ; Obeyesekere, Mandri. / Theoretical and experimental evidence for hysteresis in cell proliferation. In: Cell Cycle. 2003 ; Vol. 2, No. 1. pp. 46-52.
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