Therapeutic administration of fibronectin: Current uses and potential applications

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Fibronectins are high molecular weight glycoproteins present in body fluids and tissues that facilitate cell-to-extracellular matrix adhesion. Fibronectins are integrally involved in cell growth, differentiation, and migration, and therefore, fibronectins play important roles in numerous biologic processes. Clinical trials of fibronectin administration for selected human disorders have been conducted and suggest a beneficial effect of fibronectin in promoting corneal wound healing and in improving the clinical status of critically ill adult patients. The potential role of fibronectin as an immunotherapeutic agent in neonates with sepsis is discussed.

Original languageEnglish (US)
Pages (from-to)325-341
Number of pages17
JournalClinics in Perinatology
Volume18
Issue number2
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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