Therapeutic potential of adipose-derived stem cells in vascular growth and tissue repair

Soon Jun Hong, Dmitry O. Traktuev, Keith L. March

Research output: Contribution to journalReview article

126 Citations (Scopus)

Abstract

Purpose of review: Adipose-derived stem cells (ASCs) are readily available from autologous adipose tissue and have been demonstrated to provide significant potential for tissue rescue from, or repair of, damage in multiple animal models. These include models of myocardial infarction, heart failure, hind limb ischemia, and inflammatory conditions. Early clinical studies have now extended testing of the effects of ASC into patients. This review highlights some of the key reports underlining the potential of ASCs, focusing particularly on diseases involving the cardiovascular system, vascular growth, and tissue repair. Recent findings: Clinical applications of ASCs have begun to show early safety results and promising possibility of efficacy in patients with a range of diseases, including acute myocardial infarction, peripheral vascular disease, and soft and bony tissue defects including cranial bone loss, Crohn's-related fistula, and skin wounds. These effects are importantly based on the secretion of trophic and survival factors by these cells and by their participations in the growth and remodeling of blood vessels. These results suggest that ASCs could be a valuable therapeutic option in vascular growth and tissue repair in various clinical settings. Summary: ASCs may ultimately represent a valuable therapeutic option in tissue rescue and repair based on their ready availability, proangiogenesis and antiapoptotic factor secretion, immunomodulatory effects, and capacity for multilineage differentiation and ready expansion.

Original languageEnglish
Pages (from-to)86-91
Number of pages6
JournalCurrent Opinion in Organ Transplantation
Volume15
Issue number1
DOIs
StatePublished - Feb 2010

Fingerprint

Blood Vessels
Stem Cells
Growth
Therapeutics
Myocardial Infarction
Cutaneous Fistula
Peripheral Vascular Diseases
Acute Disease
Cardiovascular System
Adipose Tissue
Cell Survival
Ischemia
Extremities
Animal Models
Heart Failure
Safety
Bone and Bones
Wounds and Injuries

Keywords

  • Adipose-derived stem cells
  • Adipose-derived stromal cells
  • Regenerative medicine
  • Tissue engineering
  • Vascular growth

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation

Cite this

Therapeutic potential of adipose-derived stem cells in vascular growth and tissue repair. / Hong, Soon Jun; Traktuev, Dmitry O.; March, Keith L.

In: Current Opinion in Organ Transplantation, Vol. 15, No. 1, 01.02.2010, p. 86-91.

Research output: Contribution to journalReview article

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