Therapeutic removal of amyloid deposits in cutaneous amyloidosis by localised intra-lesional injections of anti-amyloid antibodies

Audra L. Clos, Cristian A. Lasagna-Reeves, Richard Wagner, Brent Kelly, George R. Jackson, Rakez Kayed

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

In the skin, amyloidosis can be found with or without systemic disease. Primary cutaneous amyloidosis defines those amyloidoses restricted to the skin without involvement of other systems. Here, we used conformation-specific antibodies to characterise both fibrillar and oligomeric amyloid aggregates in the skin from patients with cutaneous amyloidosis. Localised cutaneous amyloidosis with different morphology was reproduced in mice by intra-dermal (i.d.) and subdermal administration of amyloid-enhancing factor. Moreover, we demonstrated that conformational antibodies were effective in clearing amyloid deposits caused by localised intra-lesional injections without the necessity of an immune response. Given the accessibility and amyloid localization in this disease, direct i.d. injections of conformational antibodies could be a convenient and direct method for treatment.

Original languageEnglish (US)
Pages (from-to)904-911
Number of pages8
JournalExperimental Dermatology
Volume19
Issue number10
DOIs
StatePublished - Oct 1 2010

Keywords

  • Cutaneous amyloidosis
  • Fibrils and conformational antibodies
  • Oligomers

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

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