Therapeutic targeting of the ceramide-to-sphingosine 1-phosphate pathway in pain

Daniela Salvemini, Timothy Doyle, Michaela Kress, Grant Nicol

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations

Abstract

Approximately 20% of the population in Western countries suffers from chronic pain syndromes for which treatments are frequently insufficient or non-existent. In particular, chronic pain management with opiate/narcotic analgesics is often hampered by the development of analgesic tolerance and hyperalgesia, necessitating escalating doses to achieve pain relief. There is a major need for renewed focus on novel targets that will be effective in both neuropathic and inflammatory pain. Compelling evidence implicates ceramide-to-sphingosine 1-phosphate (S1P) pathways as contributors to pain of diverse etiologies. Moreover, S1P and its receptors are emerging as important neuronal and immune cell regulators interacting at several sites in the pain pathway. It is therefore timely and important to critically evaluate the pharmacological basis for targeting the ceramide-to-S1P pathway as an approach to pain management.

Original languageEnglish (US)
Pages (from-to)110-118
Number of pages9
JournalTrends in Pharmacological Sciences
Volume34
Issue number2
DOIs
StatePublished - Feb 1 2013

Keywords

  • FTY720
  • inflammation
  • multiple sclerosis
  • nociception

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

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