Therapy and outcomes in massive pulmonary embolism from the Emergency Medicine Pulmonary Embolism in the Real World Registry

Brian W. Lin, Donald H. Schreiber, Gigi Liu, Beau Briese, Brian Hiestand, David Slattery, Jeffrey Kline, Samuel Z. Goldhaber, Charles V. Pollack

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Study Aim: Clinical guidelines recommend fibrinolysis or embolectomy for acute massive pulmonary embolism (PE) (MPE). However, actual therapy and outcomes of emergency department (ED) patients with MPE have not previously been reported. We characterize the current management of ED patients with MPE in a US registry. Methods: A prospective, observational, multicenter registry of ED patients with confirmed PE was conducted from 2006 to 2008. Massive PE was defined as PE with an initial systolic blood pressure less than 90 mm Hg. We compared inpatient and 30-day mortality, bleeding complications, and recurrent venous thromboembolism. Results: Of 1875 patients enrolled, 58 (3.1%) had MPE. There was no difference in frequency of parenteral anticoagulation (98.3% [95% confidence interval {CI}, 90.5-101.6] vs 98.5% [95% CI, 97.9-99.1], P =.902) between patients with and without MPE. Fibrinolytic therapy and embolectomy were infrequently used but were used more in patients with MPE than in patients without MPE (12.1% [95% CI, 3.7-20.5] vs 2.4% [95% CI, 1.7-3.1], P

Original languageEnglish (US)
Pages (from-to)1774-1781
Number of pages8
JournalThe American journal of emergency medicine
Volume30
Issue number9
DOIs
StatePublished - Nov 2012
Externally publishedYes

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Emergency Medicine
Pulmonary Embolism
Registries
Confidence Intervals
Embolectomy
Hospital Emergency Service
Therapeutics
Blood Pressure
Thrombolytic Therapy
Venous Thromboembolism
Fibrinolysis
Inpatients
Guidelines
Hemorrhage
Mortality

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

Therapy and outcomes in massive pulmonary embolism from the Emergency Medicine Pulmonary Embolism in the Real World Registry. / Lin, Brian W.; Schreiber, Donald H.; Liu, Gigi; Briese, Beau; Hiestand, Brian; Slattery, David; Kline, Jeffrey; Goldhaber, Samuel Z.; Pollack, Charles V.

In: The American journal of emergency medicine, Vol. 30, No. 9, 11.2012, p. 1774-1781.

Research output: Contribution to journalArticle

Lin, Brian W. ; Schreiber, Donald H. ; Liu, Gigi ; Briese, Beau ; Hiestand, Brian ; Slattery, David ; Kline, Jeffrey ; Goldhaber, Samuel Z. ; Pollack, Charles V. / Therapy and outcomes in massive pulmonary embolism from the Emergency Medicine Pulmonary Embolism in the Real World Registry. In: The American journal of emergency medicine. 2012 ; Vol. 30, No. 9. pp. 1774-1781.
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