Therapy-related myeloid neoplasms

Magdalena Czader, Attilio Orazi

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Session 5 of 2007 Workshop of the Society for Hematopathology/European Association for Haematopathology focused on therapy-related myeloid neoplasms. This report discusses the diversity and relevance of clinical, pathologic, and genetic features and provides an update on the pathogenesis of these disorders. We highlight common diagnostic issues such as the differentiation between therapy-related myelodysplastic syndrome and therapy-related acute erythroid leukemia. As similar therapeutic interventions are frequently considered for patients with either of these diagnoses, in the current World Health Organization classification, regardless of morphologic presentation, therapy-related myeloid neoplasms are considered together as a unique clinicopathologic syndrome of therapy-related myelodysplastic syndrome/ acute myeloid leukemia. Nevertheless, recognition of the diverse morphologic features is crucial as bone marrow morphologic examination remains the first and important step of patient evaluation. We also present examples of therapy-related acute myeloid leukemias with recurrent cytogenetic abnormalities. In these cases, the precise classification is clinically important because it is associated with distinct clinical outcome.

Original languageEnglish (US)
Pages (from-to)410-425
Number of pages16
JournalAmerican journal of clinical pathology
Volume132
Issue number3
DOIs
StatePublished - Sep 1 2009

    Fingerprint

Keywords

  • Alkylating agents
  • Ionizing radiation therapy
  • Therapy-related acute myeloid leukemia
  • Therapy-related myelodysplastic syndrome
  • Therapy-related myeloid neoplasms
  • Topoisomerase II inhibitors

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this