Thermal nociception using a modified Hargreaves method in primates and humans

Zhengwen Ma, Yao Li, Yi Ping Zhang, Lisa B E Shields, Qing Xie, Guofeng Yan, Wei Liu, Guoqiang Chen, Ying Zhang, Benedikt Brommer, Xiao-Ming Xu, Yi Lu, Xuejin Chen, Christopher B. Shields

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Nociception is an important protective mechanism. The Hargreaves method, which involves measuring withdrawal latency following thermal stimulation to the paw, is commonly used to measure pain thresholds in rodents. We modified this technique to measure pain thresholds in monkeys and humans. The modified Hargreaves method was used to quantitate pain sensitivity in eight normal rhesus monkeys, 55 human volunteers, and 12 patients with spinal cord or cauda equina lesions. Thermal stimulation was delivered at 80% of maximum output, and the duration of the stimulation was set at a maximum of 10 seconds to avoid skin injury. The following withdrawal latencies were recorded: 2.7±0.12 seconds in volunteers and 3.4±0.35 seconds in neurologically intact monkeys (p>0.05). Patients with spinal cord or cauda equina lesions showed significantly increased latencies (p

Original languageEnglish (US)
Pages (from-to)229-236
Number of pages8
JournalFunctional Neurology
Volume30
Issue number4
StatePublished - Oct 1 2015

Fingerprint

Cauda Equina
Pain Threshold
Nociception
Primates
Haplorhini
Volunteers
Spinal Cord
Hot Temperature
Macaca mulatta
Rodentia
Pain
Skin
Wounds and Injuries

Keywords

  • Hargreaves
  • Monkeys
  • Pain
  • Spinal cord injury
  • Threshold

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Ma, Z., Li, Y., Zhang, Y. P., Shields, L. B. E., Xie, Q., Yan, G., ... Shields, C. B. (2015). Thermal nociception using a modified Hargreaves method in primates and humans. Functional Neurology, 30(4), 229-236.

Thermal nociception using a modified Hargreaves method in primates and humans. / Ma, Zhengwen; Li, Yao; Zhang, Yi Ping; Shields, Lisa B E; Xie, Qing; Yan, Guofeng; Liu, Wei; Chen, Guoqiang; Zhang, Ying; Brommer, Benedikt; Xu, Xiao-Ming; Lu, Yi; Chen, Xuejin; Shields, Christopher B.

In: Functional Neurology, Vol. 30, No. 4, 01.10.2015, p. 229-236.

Research output: Contribution to journalArticle

Ma, Z, Li, Y, Zhang, YP, Shields, LBE, Xie, Q, Yan, G, Liu, W, Chen, G, Zhang, Y, Brommer, B, Xu, X-M, Lu, Y, Chen, X & Shields, CB 2015, 'Thermal nociception using a modified Hargreaves method in primates and humans', Functional Neurology, vol. 30, no. 4, pp. 229-236.
Ma Z, Li Y, Zhang YP, Shields LBE, Xie Q, Yan G et al. Thermal nociception using a modified Hargreaves method in primates and humans. Functional Neurology. 2015 Oct 1;30(4):229-236.
Ma, Zhengwen ; Li, Yao ; Zhang, Yi Ping ; Shields, Lisa B E ; Xie, Qing ; Yan, Guofeng ; Liu, Wei ; Chen, Guoqiang ; Zhang, Ying ; Brommer, Benedikt ; Xu, Xiao-Ming ; Lu, Yi ; Chen, Xuejin ; Shields, Christopher B. / Thermal nociception using a modified Hargreaves method in primates and humans. In: Functional Neurology. 2015 ; Vol. 30, No. 4. pp. 229-236.
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