Theta power in the EEG of alcoholics

Madhavi Rangaswamy, Bernice Porjesz, David B. Chorlian, Keewhan Choi, Kevin A. Jones, Kongming Wang, John Rohrbaugh, Sean O'Connor, Sam Kuperman, Theodore Reich, Henri Begleiter

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Background: In this study, the magnitude and spatial distribution of theta power in the resting EEG were examined to explore the changes in the neurophysiological status of the alcoholic brain. Some state- and trait-related issues of theta power increases in the EEG of alcoholics were also examined. Methods: Absolute theta (3-7 Hz) power in eyes-closed EEGs of 307 alcohol-dependent subjects and 307 age- and gender-matched unaffected controls were compared by using a repeated-measures ANOVA for the entire region and three subregions (frontal, central, and parietal) separately. Supplementary to the main analysis, the effect of three clinical variables on absolute theta power was examined separately for each gender by using correlation and regression analyses. Gender differences in the theta log power difference between alcoholics and controls were explored by using regional repeated-measures ANOVA. Results: Increased absolute theta power was seen in alcohol-dependent subjects at all scalp locations. The theta log power increase in male alcoholics was prominent at the central and parietal regions and in female alcoholics at the parietal region when compared with the respective matched controls. Correlation of drinking variables with log theta power exhibited no group-specific differences. Conclusions: Increased tonic theta power in the EEG may reflect a deficiency in the information-processing capacity of the central nervous system in alcoholics. The theta power increase may also be an electrophysiological index of the imbalance in the excitation-inhibition homeostasis in the cortex. It is likely that the theta power increase is a trait-related phenomenon and is expressed to differing degrees in the two genders.

Original languageEnglish
Pages (from-to)607-615
Number of pages9
JournalAlcoholism: Clinical and Experimental Research
Volume27
Issue number4
StatePublished - Apr 1 2003

Fingerprint

Alcoholics
Electroencephalography
Analysis of variance (ANOVA)
Parietal Lobe
Alcohols
Analysis of Variance
Neurology
Spatial distribution
Brain
Scalp
Automatic Data Processing
Drinking
Homeostasis
Central Nervous System
Regression Analysis

Keywords

  • Absolute Power
  • Alcoholism
  • EEG
  • Theta

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Rangaswamy, M., Porjesz, B., Chorlian, D. B., Choi, K., Jones, K. A., Wang, K., ... Begleiter, H. (2003). Theta power in the EEG of alcoholics. Alcoholism: Clinical and Experimental Research, 27(4), 607-615.

Theta power in the EEG of alcoholics. / Rangaswamy, Madhavi; Porjesz, Bernice; Chorlian, David B.; Choi, Keewhan; Jones, Kevin A.; Wang, Kongming; Rohrbaugh, John; O'Connor, Sean; Kuperman, Sam; Reich, Theodore; Begleiter, Henri.

In: Alcoholism: Clinical and Experimental Research, Vol. 27, No. 4, 01.04.2003, p. 607-615.

Research output: Contribution to journalArticle

Rangaswamy, M, Porjesz, B, Chorlian, DB, Choi, K, Jones, KA, Wang, K, Rohrbaugh, J, O'Connor, S, Kuperman, S, Reich, T & Begleiter, H 2003, 'Theta power in the EEG of alcoholics', Alcoholism: Clinical and Experimental Research, vol. 27, no. 4, pp. 607-615.
Rangaswamy M, Porjesz B, Chorlian DB, Choi K, Jones KA, Wang K et al. Theta power in the EEG of alcoholics. Alcoholism: Clinical and Experimental Research. 2003 Apr 1;27(4):607-615.
Rangaswamy, Madhavi ; Porjesz, Bernice ; Chorlian, David B. ; Choi, Keewhan ; Jones, Kevin A. ; Wang, Kongming ; Rohrbaugh, John ; O'Connor, Sean ; Kuperman, Sam ; Reich, Theodore ; Begleiter, Henri. / Theta power in the EEG of alcoholics. In: Alcoholism: Clinical and Experimental Research. 2003 ; Vol. 27, No. 4. pp. 607-615.
@article{e3e40188ca6a451996fe25bae5a53fe5,
title = "Theta power in the EEG of alcoholics",
abstract = "Background: In this study, the magnitude and spatial distribution of theta power in the resting EEG were examined to explore the changes in the neurophysiological status of the alcoholic brain. Some state- and trait-related issues of theta power increases in the EEG of alcoholics were also examined. Methods: Absolute theta (3-7 Hz) power in eyes-closed EEGs of 307 alcohol-dependent subjects and 307 age- and gender-matched unaffected controls were compared by using a repeated-measures ANOVA for the entire region and three subregions (frontal, central, and parietal) separately. Supplementary to the main analysis, the effect of three clinical variables on absolute theta power was examined separately for each gender by using correlation and regression analyses. Gender differences in the theta log power difference between alcoholics and controls were explored by using regional repeated-measures ANOVA. Results: Increased absolute theta power was seen in alcohol-dependent subjects at all scalp locations. The theta log power increase in male alcoholics was prominent at the central and parietal regions and in female alcoholics at the parietal region when compared with the respective matched controls. Correlation of drinking variables with log theta power exhibited no group-specific differences. Conclusions: Increased tonic theta power in the EEG may reflect a deficiency in the information-processing capacity of the central nervous system in alcoholics. The theta power increase may also be an electrophysiological index of the imbalance in the excitation-inhibition homeostasis in the cortex. It is likely that the theta power increase is a trait-related phenomenon and is expressed to differing degrees in the two genders.",
keywords = "Absolute Power, Alcoholism, EEG, Theta",
author = "Madhavi Rangaswamy and Bernice Porjesz and Chorlian, {David B.} and Keewhan Choi and Jones, {Kevin A.} and Kongming Wang and John Rohrbaugh and Sean O'Connor and Sam Kuperman and Theodore Reich and Henri Begleiter",
year = "2003",
month = "4",
day = "1",
language = "English",
volume = "27",
pages = "607--615",
journal = "Alcoholism: Clinical and Experimental Research",
issn = "0145-6008",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Theta power in the EEG of alcoholics

AU - Rangaswamy, Madhavi

AU - Porjesz, Bernice

AU - Chorlian, David B.

AU - Choi, Keewhan

AU - Jones, Kevin A.

AU - Wang, Kongming

AU - Rohrbaugh, John

AU - O'Connor, Sean

AU - Kuperman, Sam

AU - Reich, Theodore

AU - Begleiter, Henri

PY - 2003/4/1

Y1 - 2003/4/1

N2 - Background: In this study, the magnitude and spatial distribution of theta power in the resting EEG were examined to explore the changes in the neurophysiological status of the alcoholic brain. Some state- and trait-related issues of theta power increases in the EEG of alcoholics were also examined. Methods: Absolute theta (3-7 Hz) power in eyes-closed EEGs of 307 alcohol-dependent subjects and 307 age- and gender-matched unaffected controls were compared by using a repeated-measures ANOVA for the entire region and three subregions (frontal, central, and parietal) separately. Supplementary to the main analysis, the effect of three clinical variables on absolute theta power was examined separately for each gender by using correlation and regression analyses. Gender differences in the theta log power difference between alcoholics and controls were explored by using regional repeated-measures ANOVA. Results: Increased absolute theta power was seen in alcohol-dependent subjects at all scalp locations. The theta log power increase in male alcoholics was prominent at the central and parietal regions and in female alcoholics at the parietal region when compared with the respective matched controls. Correlation of drinking variables with log theta power exhibited no group-specific differences. Conclusions: Increased tonic theta power in the EEG may reflect a deficiency in the information-processing capacity of the central nervous system in alcoholics. The theta power increase may also be an electrophysiological index of the imbalance in the excitation-inhibition homeostasis in the cortex. It is likely that the theta power increase is a trait-related phenomenon and is expressed to differing degrees in the two genders.

AB - Background: In this study, the magnitude and spatial distribution of theta power in the resting EEG were examined to explore the changes in the neurophysiological status of the alcoholic brain. Some state- and trait-related issues of theta power increases in the EEG of alcoholics were also examined. Methods: Absolute theta (3-7 Hz) power in eyes-closed EEGs of 307 alcohol-dependent subjects and 307 age- and gender-matched unaffected controls were compared by using a repeated-measures ANOVA for the entire region and three subregions (frontal, central, and parietal) separately. Supplementary to the main analysis, the effect of three clinical variables on absolute theta power was examined separately for each gender by using correlation and regression analyses. Gender differences in the theta log power difference between alcoholics and controls were explored by using regional repeated-measures ANOVA. Results: Increased absolute theta power was seen in alcohol-dependent subjects at all scalp locations. The theta log power increase in male alcoholics was prominent at the central and parietal regions and in female alcoholics at the parietal region when compared with the respective matched controls. Correlation of drinking variables with log theta power exhibited no group-specific differences. Conclusions: Increased tonic theta power in the EEG may reflect a deficiency in the information-processing capacity of the central nervous system in alcoholics. The theta power increase may also be an electrophysiological index of the imbalance in the excitation-inhibition homeostasis in the cortex. It is likely that the theta power increase is a trait-related phenomenon and is expressed to differing degrees in the two genders.

KW - Absolute Power

KW - Alcoholism

KW - EEG

KW - Theta

UR - http://www.scopus.com/inward/record.url?scp=0037392258&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037392258&partnerID=8YFLogxK

M3 - Article

VL - 27

SP - 607

EP - 615

JO - Alcoholism: Clinical and Experimental Research

JF - Alcoholism: Clinical and Experimental Research

SN - 0145-6008

IS - 4

ER -