Thiazides and calcium stones: Overrated or underused?

John J. Knoedler, Amy Krambeck

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The lifetime incidence of urolithiasis is approximately 10-15∈% in the USA, with calcium-containing stones the most common offender. Among recurrent stone formers, thiazide-type diuretics have traditionally represented first-line therapy for prevention of recurrent calcium stones. However, with improved understanding of the benefits of lifestyle modification and alternative therapies for stone prevention, the utility of thiazides as first-line agents has recently come into question. This chapter will explore the rational for thiazide usage in the prevention of recurrent calcium stone disease, evaluate the evidence in favor of and against thiazides as first-line therapy, and finally examine the cost-effective use of thiazides and their comparative effectiveness to alternative forms of treatment.

Original languageEnglish (US)
Title of host publicationPractical Controversies in Medical Management of Stone Disease
PublisherSpringer New York
Pages131-141
Number of pages11
Volume9781461495758
ISBN (Electronic)9781461495758
ISBN (Print)1461495741, 9781461495741
DOIs
StatePublished - Nov 1 2014
Externally publishedYes

Fingerprint

Thiazides
Calcium
Sodium Chloride Symporter Inhibitors
Urolithiasis
Complementary Therapies
Life Style
Therapeutics
Costs and Cost Analysis
Incidence

Keywords

  • Hypercalciuria
  • Nephrolithiasis
  • Stones kidney
  • Thiazide diuretic

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Knoedler, J. J., & Krambeck, A. (2014). Thiazides and calcium stones: Overrated or underused? In Practical Controversies in Medical Management of Stone Disease (Vol. 9781461495758, pp. 131-141). Springer New York. https://doi.org/10.1007/978-1-4614-9575-8_10

Thiazides and calcium stones : Overrated or underused? / Knoedler, John J.; Krambeck, Amy.

Practical Controversies in Medical Management of Stone Disease. Vol. 9781461495758 Springer New York, 2014. p. 131-141.

Research output: Chapter in Book/Report/Conference proceedingChapter

Knoedler, JJ & Krambeck, A 2014, Thiazides and calcium stones: Overrated or underused? in Practical Controversies in Medical Management of Stone Disease. vol. 9781461495758, Springer New York, pp. 131-141. https://doi.org/10.1007/978-1-4614-9575-8_10
Knoedler JJ, Krambeck A. Thiazides and calcium stones: Overrated or underused? In Practical Controversies in Medical Management of Stone Disease. Vol. 9781461495758. Springer New York. 2014. p. 131-141 https://doi.org/10.1007/978-1-4614-9575-8_10
Knoedler, John J. ; Krambeck, Amy. / Thiazides and calcium stones : Overrated or underused?. Practical Controversies in Medical Management of Stone Disease. Vol. 9781461495758 Springer New York, 2014. pp. 131-141
@inbook{008c2e3340924ec48492db1e61d8e9bf,
title = "Thiazides and calcium stones: Overrated or underused?",
abstract = "The lifetime incidence of urolithiasis is approximately 10-15∈{\%} in the USA, with calcium-containing stones the most common offender. Among recurrent stone formers, thiazide-type diuretics have traditionally represented first-line therapy for prevention of recurrent calcium stones. However, with improved understanding of the benefits of lifestyle modification and alternative therapies for stone prevention, the utility of thiazides as first-line agents has recently come into question. This chapter will explore the rational for thiazide usage in the prevention of recurrent calcium stone disease, evaluate the evidence in favor of and against thiazides as first-line therapy, and finally examine the cost-effective use of thiazides and their comparative effectiveness to alternative forms of treatment.",
keywords = "Hypercalciuria, Nephrolithiasis, Stones kidney, Thiazide diuretic",
author = "Knoedler, {John J.} and Amy Krambeck",
year = "2014",
month = "11",
day = "1",
doi = "10.1007/978-1-4614-9575-8_10",
language = "English (US)",
isbn = "1461495741",
volume = "9781461495758",
pages = "131--141",
booktitle = "Practical Controversies in Medical Management of Stone Disease",
publisher = "Springer New York",

}

TY - CHAP

T1 - Thiazides and calcium stones

T2 - Overrated or underused?

AU - Knoedler, John J.

AU - Krambeck, Amy

PY - 2014/11/1

Y1 - 2014/11/1

N2 - The lifetime incidence of urolithiasis is approximately 10-15∈% in the USA, with calcium-containing stones the most common offender. Among recurrent stone formers, thiazide-type diuretics have traditionally represented first-line therapy for prevention of recurrent calcium stones. However, with improved understanding of the benefits of lifestyle modification and alternative therapies for stone prevention, the utility of thiazides as first-line agents has recently come into question. This chapter will explore the rational for thiazide usage in the prevention of recurrent calcium stone disease, evaluate the evidence in favor of and against thiazides as first-line therapy, and finally examine the cost-effective use of thiazides and their comparative effectiveness to alternative forms of treatment.

AB - The lifetime incidence of urolithiasis is approximately 10-15∈% in the USA, with calcium-containing stones the most common offender. Among recurrent stone formers, thiazide-type diuretics have traditionally represented first-line therapy for prevention of recurrent calcium stones. However, with improved understanding of the benefits of lifestyle modification and alternative therapies for stone prevention, the utility of thiazides as first-line agents has recently come into question. This chapter will explore the rational for thiazide usage in the prevention of recurrent calcium stone disease, evaluate the evidence in favor of and against thiazides as first-line therapy, and finally examine the cost-effective use of thiazides and their comparative effectiveness to alternative forms of treatment.

KW - Hypercalciuria

KW - Nephrolithiasis

KW - Stones kidney

KW - Thiazide diuretic

UR - http://www.scopus.com/inward/record.url?scp=84930017175&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930017175&partnerID=8YFLogxK

U2 - 10.1007/978-1-4614-9575-8_10

DO - 10.1007/978-1-4614-9575-8_10

M3 - Chapter

AN - SCOPUS:84930017175

SN - 1461495741

SN - 9781461495741

VL - 9781461495758

SP - 131

EP - 141

BT - Practical Controversies in Medical Management of Stone Disease

PB - Springer New York

ER -