Thoracoscopic lobectomy has increasing benefit in patients with poor pulmonary function: A society of thoracic surgeons database analysis

Duykhanh P. Ceppa, Andrzej S. Kosinski, Mark F. Berry, Betty C. Tong, David H. Harpole, John D. Mitchell, Thomas A. D'Amico, Mark W. Onaitis

Research output: Contribution to journalArticle

145 Scopus citations

Abstract

Objective: Using a national database, we asked whether video-assisted thoracoscopic surgery (VATS) lobectomy is beneficial in high-risk pulmonary patients. Background: Single-institution series demonstrated benefit of VATS lobectomy over lobectomy via thoracotomy in poor pulmonary function patients [FEV1 (forced expiratory volume in 1 second) or DLCO (diffusion capacity of the lung to carbon monoxide) <60% predicted]. Methods: The STS General Thoracic Database was queried for patients having undergone lobectomy by either thoracotomy or VATS between 2000 and 2010. Postoperative pulmonary complications included those defined by the STS database. Results: In the STS database, 12,970 patients underwent lobectomy (thoracotomy, n = 8439; VATS, n = 4531) and met inclusion criteria. The overall rate of pulmonary complications was 21.7% (1832/8439) and 17.8% (806/4531) in patients undergoing lobectomy with thoracotomy and VATS, respectively (P < 0.0001). In a multivariable model of pulmonary complications, thoracotomy approach (OR = 1.25, P < 0.001), decreasing FEV1% predicted (OR = 1.01 per unit, P < 0.001) and DLCO% predicted (OR = 1.01 per unit, P < 0.001), and increasing age (1.02 per year, P < 0.001) independently predicted pulmonary complications. When examining pulmonary complications in patients with FEV1 less than 60% predicted, thoracotomy patients have markedly increased pulmonary complications when compared with VATS patients (P = 0.023). No significant difference is noted with FEV1 more than 60% predicted. Conclusions: Poor pulmonary function predicts respiratory complications regardless of approach. Respiratory complications increase at a significantly greater rate in lobectomy patients with poor pulmonary function after thoracotomy compared with VATS. Planned surgical approach should be considered while determining whether a high-risk patient is an appropriate resection candidate.

Original languageEnglish (US)
Pages (from-to)487-493
Number of pages7
JournalAnnals of surgery
Volume256
Issue number3
DOIs
StatePublished - Sep 1 2012

    Fingerprint

Keywords

  • major lung resection
  • non-small cell lung cancer
  • outcomes
  • pulmonary function
  • thoracoscopic lobectomy

ASJC Scopus subject areas

  • Surgery

Cite this

Ceppa, D. P., Kosinski, A. S., Berry, M. F., Tong, B. C., Harpole, D. H., Mitchell, J. D., D'Amico, T. A., & Onaitis, M. W. (2012). Thoracoscopic lobectomy has increasing benefit in patients with poor pulmonary function: A society of thoracic surgeons database analysis. Annals of surgery, 256(3), 487-493. https://doi.org/10.1097/SLA.0b013e318265819c