Thousands of proteins likely to have long disordered regions.

P. Romero, Z. Obradovic, C. R. Kissinger, J. E. Villafranca, E. Garner, S. Guilliot, A. Dunker

Research output: Chapter in Book/Report/Conference proceedingChapter

205 Citations (Scopus)

Abstract

Neural network predictors of protein disorder using primary sequence information were developed and applied to the Swiss Protein Database. More than 15,000 proteins were predicted to contain disordered regions of at least 40 consecutive amino acids, with more than 1,000 having especially high scores indicating disorder. These results support proposals that consideration of structure-activity relationships in proteins need to be broadened to include unfolded or disordered protein.

Original languageEnglish (US)
Title of host publicationPacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Pages437-448
Number of pages12
StatePublished - 1998
Externally publishedYes

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Proteins
Protein Databases
Structure-Activity Relationship
Amino Acids

Cite this

Romero, P., Obradovic, Z., Kissinger, C. R., Villafranca, J. E., Garner, E., Guilliot, S., & Dunker, A. (1998). Thousands of proteins likely to have long disordered regions. In Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing (pp. 437-448)

Thousands of proteins likely to have long disordered regions. / Romero, P.; Obradovic, Z.; Kissinger, C. R.; Villafranca, J. E.; Garner, E.; Guilliot, S.; Dunker, A.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 1998. p. 437-448.

Research output: Chapter in Book/Report/Conference proceedingChapter

Romero, P, Obradovic, Z, Kissinger, CR, Villafranca, JE, Garner, E, Guilliot, S & Dunker, A 1998, Thousands of proteins likely to have long disordered regions. in Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. pp. 437-448.
Romero P, Obradovic Z, Kissinger CR, Villafranca JE, Garner E, Guilliot S et al. Thousands of proteins likely to have long disordered regions. In Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 1998. p. 437-448
Romero, P. ; Obradovic, Z. ; Kissinger, C. R. ; Villafranca, J. E. ; Garner, E. ; Guilliot, S. ; Dunker, A. / Thousands of proteins likely to have long disordered regions. Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 1998. pp. 437-448
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