Thrombolytic agents: Effects of local infusion on microvascular physiology and macrovascular ultrastructure

G. J. Becker, F. E. Rabe, R. D. Hogan, Andrew Evan, T. D. Franklin, R. W. Holden, N. U. Bang, R. S. Dilley, P. J. Bendick, E. C. Klatte

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Microvascular responses in live preparations of rat cremaster muscle were studied with intravital light microscopy following infusions of streptokinase, streptokinase-plasminogen complex, or urokinase into the iliac artery. Structural changes occurring in the endothelium of the iliac arteries were documented by electron microscopy. Though no functional microvascular changes were documented, endothelial cell injury and luminal surface fibrin deposits were identified in the iliac arteries locally infused with the thrombolytic agents. In addition, platelets in various stages of activation were identified. It is concluded that the commonly employed thrombolytic agents, urokinase and streptokinase, caused injury to the endothelial cells of our animal model. It is further concluded that platelet activation, due to local endothelial injury or some other mechanism, occurred following local infusion in our animal model. The long-term effects and potential clinical implications of the findings are not known.

Original languageEnglish (US)
Pages (from-to)403-406
Number of pages4
JournalRadiology
Volume148
Issue number2
StatePublished - 1983
Externally publishedYes

Fingerprint

Fibrinolytic Agents
Iliac Artery
Streptokinase
Urokinase-Type Plasminogen Activator
Wounds and Injuries
Endothelial Cells
Animal Models
Abdominal Muscles
Platelet Activation
Fibrin
Endothelium
Electron Microscopy
Blood Platelets
Light

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Becker, G. J., Rabe, F. E., Hogan, R. D., Evan, A., Franklin, T. D., Holden, R. W., ... Klatte, E. C. (1983). Thrombolytic agents: Effects of local infusion on microvascular physiology and macrovascular ultrastructure. Radiology, 148(2), 403-406.

Thrombolytic agents : Effects of local infusion on microvascular physiology and macrovascular ultrastructure. / Becker, G. J.; Rabe, F. E.; Hogan, R. D.; Evan, Andrew; Franklin, T. D.; Holden, R. W.; Bang, N. U.; Dilley, R. S.; Bendick, P. J.; Klatte, E. C.

In: Radiology, Vol. 148, No. 2, 1983, p. 403-406.

Research output: Contribution to journalArticle

Becker, GJ, Rabe, FE, Hogan, RD, Evan, A, Franklin, TD, Holden, RW, Bang, NU, Dilley, RS, Bendick, PJ & Klatte, EC 1983, 'Thrombolytic agents: Effects of local infusion on microvascular physiology and macrovascular ultrastructure', Radiology, vol. 148, no. 2, pp. 403-406.
Becker GJ, Rabe FE, Hogan RD, Evan A, Franklin TD, Holden RW et al. Thrombolytic agents: Effects of local infusion on microvascular physiology and macrovascular ultrastructure. Radiology. 1983;148(2):403-406.
Becker, G. J. ; Rabe, F. E. ; Hogan, R. D. ; Evan, Andrew ; Franklin, T. D. ; Holden, R. W. ; Bang, N. U. ; Dilley, R. S. ; Bendick, P. J. ; Klatte, E. C. / Thrombolytic agents : Effects of local infusion on microvascular physiology and macrovascular ultrastructure. In: Radiology. 1983 ; Vol. 148, No. 2. pp. 403-406.
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AU - Becker, G. J.

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AU - Franklin, T. D.

AU - Holden, R. W.

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