Thrombolytic agents: Effects of local infusion on microvascular physiology and macrovascular ultrastructure

G. J. Becker, F. E. Rabe, R. D. Hogan, A. P. Evan, T. D. Franklin, R. W. Holden, N. U. Bang, R. S. Dilley, P. J. Bendick, E. C. Klatte

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Microvascular responses in live preparations of rat cremaster muscle were studied with intravital light microscopy following infusions of streptokinase, streptokinase-plasminogen complex, or urokinase into the iliac artery. Structural changes occurring in the endothelium of the iliac arteries were documented by electron microscopy. Though no functional microvascular changes were documented, endothelial cell injury and luminal surface fibrin deposits were identified in the iliac arteries locally infused with the thrombolytic agents. In addition, platelets in various stages of activation were identified. It is concluded that the commonly employed thrombolytic agents, urokinase and streptokinase, caused injury to the endothelial cells of our animal model. It is further concluded that platelet activation, due to local endothelial injury or some other mechanism, occurred following local infusion in our animal model. The long-term effects and potential clinical implications of the findings are not known.

Original languageEnglish (US)
Pages (from-to)403-406
Number of pages4
JournalUnknown Journal
Volume148
Issue number2
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Becker, G. J., Rabe, F. E., Hogan, R. D., Evan, A. P., Franklin, T. D., Holden, R. W., Bang, N. U., Dilley, R. S., Bendick, P. J., & Klatte, E. C. (1983). Thrombolytic agents: Effects of local infusion on microvascular physiology and macrovascular ultrastructure. Unknown Journal, 148(2), 403-406. https://doi.org/10.1148/radiology.148.2.6346388