Thrombopoietin administered during induction chemotherapy to patients with acute myeloid leukemia induces transient morphologic changes that may resemble chronic myeloproliferative disorders

Vonda K. Douglas, Martin S. Tallman, Larry D. Cripe, Lo Ann C. Peterson

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Thrombopoietin (TPO), a potent stimulator of megakaryocyte and platelet production, has been used in clinical trials to reduce thrombocytopenia after chemotherapy in patients with acute myeloid leukemia (AML). We report that TPO therapy is associated with peripheral blood and bone marrow findings that can mimic myeloproliferative disorders. Peripheral blood and bone marrow samples of 13 patients with AML who received TPO were examined. A subset of bone marrow samples exhibited hypercellularity, megakaryocytic hyperplasia, and reticulin fibrosis after TPO administration. Cases demonstrated as many as 58.4 megakaryocytes per high-power field (MHPF) compared with 3.7 MHPF in the control group. Megakaryocytic atypia, increased mitoses, emperipolesis, intrasinusoidal megakaryocytes, and thickened trabeculae also were seen. Peripheral blood findings included leukoerythroblastosis, leukocytosis, thrombocytosis, and circulating megakaryocyte nuclei. Changes resolved within 3 months after discontinuation of TPO. This rapid resolution of the morphologic abnormalities induced by TPO distinguishes these findings from those seen in true chronic myeloproliferative disorders.

Original languageEnglish (US)
Pages (from-to)844-850
Number of pages7
JournalAmerican journal of clinical pathology
Volume117
Issue number6
DOIs
StatePublished - Jun 6 2002
Externally publishedYes

Keywords

  • Bone marrow
  • Megakaryocyte
  • Myeloproliferative disorder
  • Thrombopoietin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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