Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice

Baohua Zhou, Michael R. Comeau, Thibaut De Smedt, H. Denny Liggitt, Martin E. Dahl, David B. Lewis, Dora Gyarmati, Theingi Aye, Daniel J. Campbell, Steven F. Ziegler

Research output: Contribution to journalArticle

606 Scopus citations

Abstract

The cytokine thymic stromal lymphopoietin (TSLP) has been linked to human allergic inflammatory diseases. We show here that TSLP expression was increased in the lungs of mice with antigen-induced asthma, whereas TSLP receptor -deficient mice had considerably attenuated disease. Lung-specific expression of a Tslp transgene induced airway inflammation and hyperreactivity characterized by T helper type 2 cytokines and increased immunoglobulin E. The lungs of Tslp-transgenic mice showed massive infiltration of leukocytes, goblet cell hyperplasia and subepithelial fibrosis. TSLP was capable of activating bone marrow -derived dendritic cells to upregulate costimulatory molecules and produce the T helper type 2 cell -attracting chemokine CCL17. These findings suggest that TSLP is an important factor necessary and sufficient for the initiation of allergic airway inflammation.

Original languageEnglish (US)
Pages (from-to)1047-1053
Number of pages7
JournalNature Immunology
Volume6
Issue number10
DOIs
StatePublished - Oct 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Zhou, B., Comeau, M. R., De Smedt, T., Liggitt, H. D., Dahl, M. E., Lewis, D. B., Gyarmati, D., Aye, T., Campbell, D. J., & Ziegler, S. F. (2005). Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nature Immunology, 6(10), 1047-1053. https://doi.org/10.1038/ni1247