Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice

Baohua Zhou, Michael R. Comeau, Thibaut De Smedt, H. Denny Liggitt, Martin E. Dahl, David B. Lewis, Dora Gyarmati, Theingi Aye, Daniel J. Campbell, Steven F. Ziegler

Research output: Contribution to journalArticle

593 Citations (Scopus)

Abstract

The cytokine thymic stromal lymphopoietin (TSLP) has been linked to human allergic inflammatory diseases. We show here that TSLP expression was increased in the lungs of mice with antigen-induced asthma, whereas TSLP receptor -deficient mice had considerably attenuated disease. Lung-specific expression of a Tslp transgene induced airway inflammation and hyperreactivity characterized by T helper type 2 cytokines and increased immunoglobulin E. The lungs of Tslp-transgenic mice showed massive infiltration of leukocytes, goblet cell hyperplasia and subepithelial fibrosis. TSLP was capable of activating bone marrow -derived dendritic cells to upregulate costimulatory molecules and produce the T helper type 2 cell -attracting chemokine CCL17. These findings suggest that TSLP is an important factor necessary and sufficient for the initiation of allergic airway inflammation.

Original languageEnglish (US)
Pages (from-to)1047-1053
Number of pages7
JournalNature Immunology
Volume6
Issue number10
DOIs
StatePublished - Oct 2005
Externally publishedYes

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Inflammation
Lung
Chemokine CCL17
Cytokines
Th2 Cells
Goblet Cells
Transgenes
Dendritic Cells
Immunoglobulin E
Transgenic Mice
Hyperplasia
Leukocytes
Fibrosis
Up-Regulation
Asthma
Bone Marrow
thymic stromal lymphopoietin
Antigens

ASJC Scopus subject areas

  • Immunology

Cite this

Zhou, B., Comeau, M. R., De Smedt, T., Liggitt, H. D., Dahl, M. E., Lewis, D. B., ... Ziegler, S. F. (2005). Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nature Immunology, 6(10), 1047-1053. https://doi.org/10.1038/ni1247

Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. / Zhou, Baohua; Comeau, Michael R.; De Smedt, Thibaut; Liggitt, H. Denny; Dahl, Martin E.; Lewis, David B.; Gyarmati, Dora; Aye, Theingi; Campbell, Daniel J.; Ziegler, Steven F.

In: Nature Immunology, Vol. 6, No. 10, 10.2005, p. 1047-1053.

Research output: Contribution to journalArticle

Zhou, B, Comeau, MR, De Smedt, T, Liggitt, HD, Dahl, ME, Lewis, DB, Gyarmati, D, Aye, T, Campbell, DJ & Ziegler, SF 2005, 'Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice', Nature Immunology, vol. 6, no. 10, pp. 1047-1053. https://doi.org/10.1038/ni1247
Zhou, Baohua ; Comeau, Michael R. ; De Smedt, Thibaut ; Liggitt, H. Denny ; Dahl, Martin E. ; Lewis, David B. ; Gyarmati, Dora ; Aye, Theingi ; Campbell, Daniel J. ; Ziegler, Steven F. / Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. In: Nature Immunology. 2005 ; Vol. 6, No. 10. pp. 1047-1053.
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